3-(噻吩-2-基)丙烯酸甲酯合成路线 （共 26 条）
反应条件
piperidine; mercapto acetic acid ethylester Behandeln des Reaktionsprodukts mit Natriummethylat in Aether und Erhitzen des danach isolierten Reaktionsprodukts mit wss. Schwefelsaeure;
参考文献
Wynberg et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 1972,1974
反应条件
1: NaOH, MeOH / 0.33 h / 20 °C 2: oxalyl chloride / toluene / 80 °C View Scheme
参考文献
Vallgarda; Hacksell
Tetrahedron Letters, 1991 , vol. 32, # 40 p. 5625 - 5628
反应条件
oxygen; palladium diacetate; toluene-4-sulfonic acid in water T=100°C; P=6080.41 Torr; 24 h; Autoclave;
参考文献
Wang, Azhong; Jiang, Huanfeng
Journal of Organic Chemistry, 2010 , vol. 75, # 7 p. 2321 - 2326
反应条件
methanol; sodium hydroxide T=20°C; 0.333333 h;
参考文献
Vallgarda; Hacksell
Tetrahedron Letters, 1991 , vol. 32, # 40 p. 5625 - 5628
反应条件
diisobutylaluminium hydride in tetrahydrofuran
参考文献
The Hospital for Sick Children
Patent: US2006/58297 A1, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate P=2327.2 Torr; 11 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 21 p. 3858 - 3872
反应条件
methanol; sodium hydroxide T=20°C; 0.333333 h;
参考文献
Vallgarda; Hacksell
Tetrahedron Letters, 1991 , vol. 32, # 40 p. 5625 - 5628
反应条件
palladium diacetate; tetrabutyl-ammonium chloride; potassium carbonate in N,N-dimethyl-formamide
T=50°C; 19 h;
参考文献
Vallgarda; Appelberg; Arvidsson; Hjorth; Svensson; Hacksell
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1485 - 1493
参考文献
Larock; Leach; Bjorge
Tetrahedron Letters, 1982 , vol. 23, # 7 p. 715 - 718
反应条件
palladium diacetate; triethylamine; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in N,N-dimethyl-formamide
T=120°C; Heck Reaction; 24 h; Inert atmosphere;
参考文献
Tengho Toguem, Serge-Mitherand; Malik, Imran; Hussain, Munawar; Iqbal, Jamshed; Villinger, Alexander; Langer, Peter
Tetrahedron, 2013 , vol. 69, # 1 p. 160 - 173
