3-(噻吩-2-基)丙烯酸甲酯合成路线 （共 26 条）
反应条件
thionyl chloride
10 h; Heating / reflux;
参考文献
The Hospital for Sick Children
Patent: US2006/58297 A1, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
(Ph)2SiH2; sodium carbonate; 3-methyl-P-phenylphospholane oxide in toluene
T=100°C; Wittig type reaction; 24 h; Inert atmosphere; stereoselective reaction;
参考文献
O'Brien, Christopher J.; Nixon, Zachary S.; Holohan, Andrew J.; Kunkel, Stephen R.; Tellez, Jennifer L.; Doonan, Bryan J.; Coyle, Emma E.; Lavigne, Florie; Kang, Lauren J.; Przeworski, Katherine C.
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15281 - 15289
反应条件
1: With sodium in methanol; toluene
T=30°C; Claisen-Schmidt condensation;
2: With sulfuric acid in methanol
2 h; Heating;
参考文献
Hatsuda, Masanori; Kuroda, Tooru; Seki, Masahiko
Synthetic Communications, 2003 , vol. 33, # 3 p. 427 - 434
反应条件
piperidine in pyridine
T=100°C; Doebner condensation; 3 h;
参考文献
Garzino, Frederic; Meou, Alain; Brun, Pierre
Helvetica Chimica Acta, 2002 , vol. 85, # 7 p. 1989 - 1998
反应条件
1: dimethyl methoxycarbonylmethanephosphonate With sodium hydride in tetrahydrofuran
T=20°C; Horner-Wadsworth-Emmons Olefination; 0.0833333 h;
2: thiophene-2-carbaldehyde in tetrahydrofuran
T=20°C; Horner-Wadsworth-Emmons Olefination; 15 h;
参考文献
Bengtsson, Christoffer; Nelander, Hanna; Almqvist, Fredrik
Chemistry - A European Journal, 2013 , vol. 19, # 30 p. 9916 - 9922
反应条件
potassium dihydrogenphosphate; 5 Pd(II)/C(eggshell) in ethanol; water
Heck reaction; 4 h; Reflux;
参考文献
Yuan, Yan-Qin; Guo, Sheng-Rong
Synthetic Communications, 2012 , vol. 42, # 7 p. 1059 - 1069
反应条件
palladium diacetate in 1,4-dioxane; acetic acid
T=100°C; 8 h;
参考文献
Fujiwara, Yuzo; Maruyama, Osamu; Yoshidomi, Michiaki; Taniguchi, Hiroshi
Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 851 - 855
反应条件
Wittig olefination; Title compound not separated from byproducts.;
参考文献
Thiemann, Thies; Watanabe, Masataka; Tanaka, Yasuko; Mataka, Shuntaro
New Journal of Chemistry, 2004 , vol. 28, # 5 p. 578 - 584
反应条件
sodium carbonate in diethyl ether; hexane
T=35°C; Wittig olefination; 1.5 h; sonification;
参考文献
Watanabe, Masataka; Morais, Goreti Ribeiro; Mataka, Shuntaro; Ideta, Keiko; Thiemann, Thies
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2005 , vol. 60, # 8 p. 909 - 915
反应条件
triphenyl phosphite; tri-n-butyl-arsine; potassium carbonate in tetrahydrofuran; acetonitrile
17 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Shi, Lilan; Wang, Weibo; Wang, Yucheng; Huang, Yao-Zeng
Journal of Organic Chemistry, 1989 , vol. 54, # 9 p. 2027 - 2028
