5-甲基噻吩-2-羧酸乙酯合成路线 （共 4 条）
反应条件
sulfuric acid in ethanol
参考文献
The Institutes for Pharmaceutical Discovery, Inc. A Corporation of the State of Delaware
Patent: US2003/166668 A1, 2003 ;
反应条件
sulfuric acid
72 h; Reflux;
参考文献
MERCK PATENT GMBH
Patent: WO2009/106203 A1, 2009 ;
Location in patent: Page/Page column 63 ;
WO 2009/106203 A1
反应条件
1: 2-methyl-thiophene With n-butyllithium in tetrahydrofuran
T=0°C; 3 h;
2: chloroformic acid ethyl ester in tetrahydrofuran
T=0 - 20°C;
参考文献
Suaifan, Ghadeer A.R.Y.; Goodyer, Claire L.M.; Threadgill, Michael D.
Molecules, 2010 , vol. 15, # 5 p. 3121 - 3134
反应条件
iron (III) acetylacetonate
T=140°C; 6 h; Inert atmosphereAutoclave;
参考文献
Khusnutdinov; Shchadneva; Baiguzina; Mukminov; Mayakova; Smirnov; Dzhemilev
Petroleum Chemistry, 2008 , vol. 48, # 6 p. 471 - 478
