5-氯硫代苯-2-甲酸乙酯合成路线 （共 11 条）
反应条件
1: 5-Bromo-2-chloro-thiophene With magnesium; ethylene dibromide in tetrahydrofuran 1.5 h; sonification; 2: diethyl dicarbonate With boron trifluoride diethyl etherate in tetrahydrofuran T=20°C; Barbier carboxylation; 5 h;
参考文献
Lee, Adam Shih-Yuan; Wu, Chih-Chiang; Lin, Li-Shin; Hsu, Hsiu-Fu
Synthesis, 2004 , # 4 p. 568 - 572
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Journal of the American Chemical Society, , vol. 76, p. 5131
反应条件
molybdenum hexacarbonate T=150°C; 6 h; Inert atmosphereAutoclave;
参考文献
Khusnutdinov; Shchadneva; Baiguzina; Mukminov; Mayakova; Smirnov; Dzhemilev
Petroleum Chemistry, 2008 , vol. 48, # 6 p. 471 - 478
反应条件
molybdenum hexacarbonate T=150°C; 6 h; Inert atmosphereAutoclave;
参考文献
Khusnutdinov; Shchadneva; Baiguzina; Mukminov; Mayakova; Smirnov; Dzhemilev
Petroleum Chemistry, 2008 , vol. 48, # 6 p. 471 - 478
反应条件
1: With pyridine; iodine; copper(II) oxide 24 h; Reflux; 2: With potassium carbonate 8 h; Reflux;
参考文献
Yin, Guodong; Gao, Meng; Wang, Zihua; Wu, Yandong; Wu, Anxin
Bulletin of the Chemical Society of Japan, 2008 , vol. 81, # 3 p. 369 - 372
反应条件
molybdenum hexacarbonate T=150°C; 6 h; Inert atmosphereAutoclave;
参考文献
Petroleum Chemistry, , vol. 48, # 6 p. 471 - 478
参考文献
Journal of the Chemical Society, , p. 547
反应条件
methanol; hydrazine hydrate
参考文献
Buu-Hoi et al.
Journal of the Chemical Society, 1953 , p. 547
反应条件
1: With lithium aluminium tetrahydride in diethyl ether T=20°C; 18 h; 2: With sodium hydroxide; water in diethyl ether
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/2181 A2, 2007 ;
Location in patent: Page/Page column 135-136 ;
WO 2007/002181 A2
