1.1: hydrogen bromide; acetic acid / 2 h / 10 - 20 °C 2.1: triethylamine / acetonitrile / 2.5 h / 70 °C 3.1: 2-(trifluoromethyl)phenyllithium / tetrahydrofuran; hexane / 0.83 h / -65 - -55 °C / Inert atmosphere 3.2: 1.5 h / -65 °C / Inert atmosphere 3.3: Inert atmosphere 4.1: ethanol 5.1: sodium hydroxide / water View Scheme

1.1: hydrogen bromide; acetic acid / 2 h / 10 - 20 °C 2.1: triethylamine / acetonitrile / 2.5 h / 70 °C 3.1: 2-(trifluoromethyl)phenyllithium / tetrahydrofuran; hexane / 0.83 h / -65 - -55 °C / Inert atmosphere 3.2: 1.5 h / -65 °C / Inert atmosphere 3.3: Inert atmosphere 4.1: Chiralpak AD column / ethanol; hexane / Resolution of racemate; HPLC conditions View Scheme

1: hydrogen bromide; acetic acid / 2 h / 10 - 20 °C 2: triethylamine / acetonitrile / 2.5 h / 70 °C View Scheme

1.1: hydrogen bromide; acetic acid / 2 h / 10 - 20 °C 2.1: triethylamine / acetonitrile / 2.5 h / 70 °C 3.1: 2-(trifluoromethyl)phenyllithium / tetrahydrofuran; hexane / 0.83 h / -65 - -55 °C / Inert atmosphere 3.2: 1.5 h / -65 °C / Inert atmosphere 3.3: Inert atmosphere 4.1: Chiralpak AD column / ethanol; hexane / Resolution of racemate; HPLC conditions View Scheme

1.1: hydrogen bromide; acetic acid / 2 h / 10 - 20 °C 2.1: triethylamine / acetonitrile / 2.5 h / 70 °C 3.1: 2-(trifluoromethyl)phenyllithium / tetrahydrofuran; hexane / 0.83 h / -65 - -55 °C / Inert atmosphere 3.2: 1.5 h / -65 °C / Inert atmosphere 3.3: Inert atmosphere View Scheme