反应条件
1: 2-(2-hydroxy)ethyl-2-methyl-1,3-dioxolane With sodium hydride in N,N-dimethyl-formamide
deprotonation; 0.25 h;
2: benzyl bromide in N,N-dimethyl-formamide
T=20°C; Alkylation; 0.5 h; Further stages.;
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961