4-(2-羟乙基)-2,2-二甲基-1,3-二氧戊环合成路线 （共 21 条）
反应条件
oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine 1.) CH2Cl2, -78 deg C, 2.) -78 deg C to room temp.; Multistep reaction;
参考文献
Guindon, Yvan; Yoakim, Christiane; Bernstein, Michael A.; Morton, Howard E.
Tetrahedron Letters, 1985 , vol. 26, # 9 p. 1185 - 1188
反应条件
pyridinium chlorochromate in dichloromethane
Ambient temperature;
参考文献
Adiyaman, Mustafa; Li, Hongwei; Lawson, John A.; Hwang, Seong-Woo; Khanapure, Subhash P.; FitzGerald, Garret A.; Rokach, Joshua
Tetrahedron Letters, 1997 , vol. 38, # 19 p. 3339 - 3342
反应条件
molecular sieve; sodium acetate; pyridinium chlorochromate in dichloromethane
T=20°C;
参考文献
Guo, Zhiwei; Padmakumar, Raghavakaimal; Hollingsworth, Rawle I.; Radhakrishnan; Nandakumar; Fraser-Reid, Bert
Synlett, 2003 , # 7 p. 1067 - 1069
反应条件
1: pyridine / 24 h
2: 1.) 4-chlorophenyl selenide, 2.) 30percent H2O2 / 1.) ethanol, reflux, 2 h, 2.) a) ethanol, THF, RT, 8 h, b) ethanol, THF, 60 deg C, 12 h
View Scheme
参考文献
Malanga, Corrado; Menicagli, Rita; Lardicci, Luciano
Gazzetta Chimica Italiana, 1992 , vol. 122, # 1 p. 45 - 50
反应条件
bromine; triphenylphosphine in N,N-dimethyl-formamide
1 h; Ambient temperature;
参考文献
Arth, Hans-Lothar; Sinerius, Gudrun; Fessner, Wolf-Dieter
Liebigs Annalen, 1995 , # 11 p. 2037 - 2042
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
1) 0-5 deg C, 3.5 h; 2) rt, 6 h;
参考文献
Gage, Jennifer L.; Branchaud, Bruce P.
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 831 - 837
参考文献
Malanga, Corrado; Menicagli, Rita; Lardicci, Luciano
Gazzetta Chimica Italiana, 1992 , vol. 122, # 1 p. 45 - 50
反应条件
tetrachloromethane; triphenylphosphine
48 h; Yield given;
参考文献
Huerta; Gomez; Yus
Tetrahedron, 1996 , vol. 52, # 24 p. 8333 - 8340
参考文献
Malanga, Corrado; Menicagli, Rita; Lardicci, Luciano
Gazzetta Chimica Italiana, 1992 , vol. 122, # 1 p. 45 - 50
反应条件
1: 81 percent / pyridine / 24 h / 0 - 20 °C
View Scheme
参考文献
Lewandowska, Elzbieta; Lalama, Jennifer; Yuan, Chong-Sheng; Wnuk, Stanislaw F.
Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 9 p. 1747 - 1755
