8-甲氧基-2H-色烯-3-羧酸合成路线 （共 6 条）
反应条件
sodium hydroxide 6 h; Heating;
参考文献
Wise, Lawrence D.; DeWald, Horace A.; Hawkins, Elma S.; Reynolds, Donna M.; Heffner, Thomas G.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 688 - 691
反应条件
1: 1,4-diazabicyclo[2.2.2]octane 2: aq. NaOH View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 16 p. 3927 - 3930
反应条件
sodium hydroxide Heating;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 4 p. 344 - 347
反应条件
hydrogen; palladium on activated charcoal in acetic acid 12 h; Ambient temperature;
参考文献
Shiratsuchi; Kawamura; Akashi; Fujii; Ishihama; Uchida
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 2 p. 632 - 641
反应条件
1: SOCl2 / benzene / 3 h / Heating
2: Et3N / benzene
View Scheme
参考文献
Gupta, R. C.; Pratap, Ram; Prasad, C. R.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 4 p. 344 - 347
反应条件
hydrogenchloride; diphenyl phosphoryl azide; triethylamine
1.) toluene, 80-85 deg C, 1.5 h, 2.) reflux, 2 h; Multistep reaction;
参考文献
Holmberg, Paer; Sohn, Daniel; Leideborg, Robert; Caldirola, Patrizia; Zlatoidsky, Pavel; Hanson, Sverker; Mohell, Nina; Rosqvist, Susanne; Nordvall, Gunnar; Johansson, Anette M.; Johansson, Rolf
Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 3927 - 3930
