8-甲氧基-2H-苯并吡喃-3-甲腈合成路线 （共 6 条）
反应条件
1,4-diaza-bicyclo[2.2.2]octane 20 h; Heating;
参考文献
Wise, Lawrence D.; DeWald, Horace A.; Hawkins, Elma S.; Reynolds, Donna M.; Heffner, Thomas G.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 688 - 691
反应条件
1: hydroxylamine hydrochloride / dimethyl sulfoxide / 90 °C 2: hydroxylamine hydrochloride; dimethyl sulfoxide / 90 °C View Scheme
参考文献
Synlett, , # 15 art. no. D12411ST, p. 2223 - 2227
反应条件
sodium hydroxide 6 h; Heating;
参考文献
Wise, Lawrence D.; DeWald, Horace A.; Hawkins, Elma S.; Reynolds, Donna M.; Heffner, Thomas G.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 688 - 691
反应条件
1: 10percent NaOH / Heating
2: SOCl2 / benzene / 3 h / Heating
3: Et3N / benzene
View Scheme
参考文献
Gupta, R. C.; Pratap, Ram; Prasad, C. R.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 4 p. 344 - 347
反应条件
hydroxylamine hydrochloride; sodium hydrogencarbonate in ethanol; water
3 h; Heating;
参考文献
Riffaud; Dupont; Rene; Royer
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 6 p. 577 - 581
反应条件
1: aq. NaOH
2: (PhO)2P(O)N3; Et3N; HCl
View Scheme
参考文献
Wise, Lawrence D.; DeWald, Horace A.; Hawkins, Elma S.; Reynolds, Donna M.; Heffner, Thomas G.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 688 - 691
