7-溴-2,3-二氢-1,4-苯并氮杂卓-5(4H)-酮合成路线 (共 3 条)
反应条件
1: With sodium azide in benzene
T=0°C;
2: With sulfuric acid in benzene
T=5 - 20°C;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2004/69244 A1, 2004 ;
Location in patent: Page/Page column 98 ;
反应条件
1: With trifluoroacetic acid in dichloromethane
2: With triethylamine in toluene
T=100°C;
参考文献
GLAXO GROUP LIMITED
Patent: US2010/174065 A1, 2010 ;
Location in patent: Page/Page column 27 ;
反应条件
bromine in acetic acid
4 h; Ambient temperature;
参考文献
Thyagarajan,G. et al.
Indian Journal of Chemistry, 1968 , vol. 6, p. 625 - 627