1,3,4,5-四氢-苯并[B][1,4]二氮杂革-2-酮合成路线

参考文献

CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; HEWITT, Michael, C.; TAYLOR, Alexander, M.; HARMANGE, Jean-Christophe
Patent: WO2012/151512 A2, 2012 ;
Location in patent: Page/Page column 113-114 ;

95-54-51,2-苯二胺+

79-10-7丙烯酸

5755-07-71,3,4,5-四氢-苯并[B][1,4]二氮杂革-2-酮

参考文献

Baraldi, Pier Giovanni; Ruggiero, Emanuela; Tabrizi, Mojgan Aghazadeh
Journal of Heterocyclic Chemistry, 2014 , vol. 51, # 1 p. 101 - 105

930-21-22-氮杂环丁酮+

615-36-12-溴苯胺

5755-07-71,3,4,5-四氢-苯并[B][1,4]二氮杂革-2-酮+

682341-17-91-(2-氨基苯基)-2-氮杂环丁酮

参考文献

Journal of the American Chemical Society, , vol. 126, # 11 p. 3529 - 3533

682341-17-91-(2-氨基苯基)-2-氮杂环丁酮

5755-07-71,3,4,5-四氢-苯并[B][1,4]二氮杂革-2-酮

参考文献

Klapars, Artis; Parris, Sean; Anderson, Kevin W.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2004 , vol. 126, # 11 p. 3529 - 3533

18523-47-2+

39145-59-0苯-1,2-二胺盐酸盐

5755-07-71,3,4,5-四氢-苯并[B][1,4]二氮杂革-2-酮

参考文献

Doebelin, Christelle; Schmitt, Martine; Antheaume, Cyril; Bourguignon, Jean-Jacques; Bihel, Frederic
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11335 - 11341

930-21-22-氮杂环丁酮+

615-43-02-碘苯胺

5755-07-71,3,4,5-四氢-苯并[B][1,4]二氮杂革-2-酮+

682341-17-91-(2-氨基苯基)-2-氮杂环丁酮

参考文献

Journal of the American Chemical Society, , vol. 126, # 11 p. 3529 - 3533

1336-21-6氨水+

95-54-51,2-苯二胺+

79-10-7丙烯酸

5755-07-71,3,4,5-四氢-苯并[B][1,4]二氮杂革-2-酮

参考文献

US5536718 A1, ;
US 5536718 A