4-羟基-2-甲基苯甲酸甲酯合成路线 （共 13 条）
反应条件
potassium carbonate in acetone 19 h; Heating;
参考文献
Shishido; Yamashita; Hiroya; Fukumoto; Kametani
Tetrahedron, 1989 , vol. 45, # 18 p. 5791 - 5804
反应条件
1: 97 percent / potassium carbonate / acetone / 19 h / Heating 2: 100 percent / LiAlH4, Celite / tetrahydrofuran / 2 h / 0 - 20 °C 3: 93 percent / PCC, Celite, florosil / CH2Cl2 / 1.3 h / Ambient temperature View Scheme
参考文献
Shishido KJ.; Yamashita; Hiroya; Fukumoto; Kametani
Tetrahedron Letters, 1989 , vol. 30, # 1 p. 111 - 112
反应条件
triethylamine; palladium diacetate
T=80°C; P=2250.23 Torr; 5 h;
参考文献
Galderma Research and Development S.N.C.
Patent: US6689922 B1, 2004 ;
Location in patent: Page column 85-86 ;
反应条件
thionyl chloride in methanol; water; ethyl acetate
参考文献
AJINOMOTO CO. INC.
Patent: US2012/59149 A1, 2012 ;
反应条件
thionyl chloride
T=0 - 60°C;
参考文献
Ajinomoto Co., Inc.; TAKAHASHI, Daisuke
Patent: EP2612845 A1, 2013 ;
Location in patent: Paragraph 0269; 0270 ;
反应条件
1: With potassium hydrogencarbonate in N,N-dimethyl-formamide
T=20 - 40°C; 3 h;
2: With water in N,N-dimethyl-formamide
T=40°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157330 A1, 2008 ;
Location in patent: Page/Page column 83 ;
反应条件
in diethyl ether
T=20°C;
参考文献
Sebej, Peter; Lim, Bum Hee; Park, Bong Ser; Givens, Richard S.; Klan, Petr
Organic Letters, 2011 , vol. 13, # 4 p. 644 - 647
参考文献
Shishido; Yamashita; Hiroya; Fukumoto; Kametani
Tetrahedron, 1989 , vol. 45, # 18 p. 5791 - 5804
反应条件
T=120°C; Diels-Alder reaction; 4 h;
参考文献
Barbero, Asuncion; Pulido, Francisco J.
Synthesis, 2004 , # 3 p. 401 - 404
反应条件
(i) (hydrolysis), (ii) /BRN= 1098229/, H2SO4; Multistep reaction;
参考文献
Fujio,M. et al.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 2127 - 2133
