4-甲氧基-2-硝基溴苄合成路线 （共 15 条）
反应条件
1: 5 h / Heating 2: 47 percent / NaH / 1,2-dimethoxy-ethane / 2 h / Heating 3: 98 percent / H2, morpholine / 5 percent Rh/C / ethanol; methanol / 4 h / 18100.2 Torr / Ambient temperature 4: 86 percent / HCOONa / 3 h / Heating 5: 47 percent / K2CO3, Cu, CuBr / dimethylsulfoxide / 24 h / 160 °C 6: 92 percent / 6 M aq. NaOH / ethanol / 1 h / Heating View Scheme
参考文献
Jorgensen, Tine Krogh; Andersen, Knud Erik; Lau, Jesper; Madsen, Peter; Huusfeldt, Per Olaf
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 1 p. 57 - 64
反应条件
potassium cyanide in tetrahydrofuran; water
参考文献
JANSSEN PHARMACEUTICA NV; ORTHO-CLINICAL DIAGNOSTICS, INC; LIN, Ronghui; SALTER, Rhys; DECORY, Thomas R.; HRYHORENKO, Eric; REMMERIE, Bart M.; SANKARAN, Banumathi
Patent: WO2014/31584 A1, 2014 ;
Location in patent: Paragraph 49-50 ;
反应条件
in tetrahydrofuran; ethanol; water
T=0 - 20°C; 4 h;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2006/103559 A1, 2006 ;
Location in patent: Page/Page column 45 ;
WO 2006/103559 A1
参考文献
Doherty, James B.; Chen, Meng-Hsin; Liu, Luping; Natarajan, Swaminathan R.; Tynebor, Robert M.
Patent: US2004/97575 A1, 2004 ;
Location in patent: Page 9 ;
反应条件
1: 75 percent / bis(tetrabutylammonium)dichromate / CHCl3 / 0.17 h / Heating
2: 1) n-Butyllithium / 1) a) -78 deg C, b) room temperature, 1.5 h, 2) THF, a) - 78 deg C, 0.5 h, b) room temperature, 16 h
View Scheme
参考文献
Mohan, Raju; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1238 - 1246
