2-(N-Boc-N-甲基氨基)乙醇合成路线 （共 11 条）
反应条件
in acetonitrile T=20°C; Condensation;
参考文献
Methylgene, Inc.
Patent: US2007/4675 A1, 2007 ;
Location in patent: Page/Page column 92-93 ;
US 20070004675 A1
反应条件
in chloroform; ethyl acetate
参考文献
Takeda Chemical Industries, Ltd
Patent: US4962113 A1, 1990 ;
反应条件
di-tert-butyl dicarbonate in tetrahydrofuran; water T=20°C; 18 h;
参考文献
Zeneca Limited; Zeneca Pharma S. A.
Patent: US6362336 B1, 2002 ;
Location in patent: Example 54 ;
US 6362336 B1
反应条件
in diethyl ether; dichloromethane
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in ethylene glycol dimethyl ether T=-15°C; 0.0166667 h; 2: With sodium tetrahydroborate in ethylene glycol dimethyl ether; water T=-15°C;
参考文献
Tetrahedron Letters, , vol. 50, # 6 p. 611 - 613
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran T=20°C; 1 h;
参考文献
INSTITUT CURIE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Patent: US2011/152252 A1, 2011 ;
Location in patent: Page/Page column 16 ;
反应条件
1: 80 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 14 h 2: 70 percent / 55percent aq. hydrazine hydrate / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 23, # 17 p. 2443 - 2449
反应条件
Dess-Martin periodane in dichloromethane T=0 - 20°C; 3 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/120098 A1, 2007 ;
Location in patent: Page/Page column 88 ;
WO 2007/120098 A1
反应条件
in dichloromethane; dimethyl sulfoxide; ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US5888972 A1, 1999 ;
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 14 h;
参考文献
Synthetic Communications, , vol. 23, # 17 p. 2443 - 2449
