4-溴-2,6-二甲基苯腈合成路线 （共 14 条）
反应条件
1: 4-bromo-2,6-dimethylbenzenamine With hydrogenchloride; sodium nitrite in water T=0 - 5°C; 0.5 h; Sonication; 2: copper (I) cyanide With potassium cyanide in water T=70°C; 0.5 h;
参考文献
Ferring B.V.
Patent: EP1512687 A1, 2005 ;
Location in patent: Page/Page column 8-9 ;
反应条件
copper (I) cyanide in water; toluene T=0 - 47°C; 3.5 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/130853 A1, 2008 ;
Location in patent: Page/Page column 25-26 ;
WO 2008/130853 A1
反应条件
1: 4-bromo-2,6-dimethylbenzenamine With hydrogenchloride; sodium nitrite T=0 - 5°C; Diazotization; 0.5 h; 2: copper (I) cyanide With hydrogenchloride in toluene T=0 - 50°C; Substitution; Further stages.;
参考文献
Xu; Kiang; Lee; Lobkovsky; Emmott
Journal of the American Chemical Society, 2000 , vol. 122, # 35 p. 8376 - 8391
反应条件
1: 4-bromo-2,6-dimethylbenzenamine With hydrogenchloride; sodium nitrite in water T=0 - 5°C; 0.5 h; Sonication; 2: copper (I) cyanide; potassium cyanide With sodium hydrogencarbonate in water T=70°C; Sandmeyer Reaction; 0.5 h;
参考文献
Ferring B.V.
Patent: EP1449844 A1, 2004 ;
Location in patent: Page 23 ;
EP 1449844 A1
反应条件
1: 4-bromo-2,6-dimethylbenzenamine With hydrogenchloride; sodium nitrate in water T=0°C; Sonication; 2: With sodium carbonate in water pH=7; 3: potassium cyanide With copper(l) iodide in water T=70°C;
参考文献
RESVERLOGIX CORP.; HANSEN, Henrik, C.; WAGNER, Gregory, S.; ATTWELL, Sarah, C.; MCLURE, Kevin, G.; KULIKOWSKI, Ewelina, B.
Patent: WO2010/123975 A1, 2010 ;
Location in patent: Page/Page column 107-110 ;
反应条件
sodium hydrogencarbonate in water T=70°C; 0.5 h;
参考文献
WO2007/87488 A2, ;
Page/Page column 26-27 ;
反应条件
1: 4-bromo-2,6-dimethylbenzenamine With hydrogenchloride in water T=90°C; 1 h; 2: With sodium nitrite in water T=0°C; 3: sodium cyanide; copper (I) cyanide
参考文献
US2010/222345 A1, ;
Page/Page column 96 ;
反应条件
sodium carbonate; sodium nitrite in water
参考文献
Ashworth, Doreen; Pitt, Gary R W; Hudson, Peter; Yea, Christopher; Franklin, Richard J; Semple, Graeme; Jenkins, David Paul
Patent: US2004/38962 A1, 2004 ;
反应条件
in water; toluene T=0 - 50°C; 5 h;
参考文献
WO2006/20879 A1, ;
Page/Page column 55-56 ;
WO 2006/020879 A1
反应条件
Cu(I)CN in water T=70°C;
参考文献
Chemistry - A European Journal, , vol. 16, # 9 p. 2830 - 2842
