3-(2-氨基苯基)-1-丙醇合成路线 （共 12 条）
反应条件
1: 1) 2 N HCl, NaNO2, 2) NaN3 / 1) H2O, 30 min, 2) H2O, 3 h 2: 74 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 1) 0 deg C, 1 h, 2) r.t., 24 htmp 3: 92 percent / hydrazine hydrate / tetrahydrofuran; ethanol / 1) r.t., 16 h, 2) 70 deg C, 8 h View Scheme
参考文献
Molina, Pedro; Alajarin, Mateo; Vidal, Angel
Journal of Organic Chemistry, 1993 , vol. 58, # 7 p. 1687 - 1695
反应条件
potassium carbonate; [pentamethylcyclopentadienylRhCl2]2 in acetone T=100°C; 20 h;
参考文献
Fujita, Ken-Ichi; Takahashi, Yoshinori; Owaki, Maki; Yamamoto, Kazunari; Yamaguchi, Ryohei
Organic Letters, 2004 , vol. 6, # 16 p. 2785 - 2788
反应条件
1-methyl-1H-imidazole; [2,2']bipyridinyl; 2,2,6,6-tetramethyl-piperidine-N-oxyl; copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=60°C; 24 h; Molecular sieve;
参考文献
Green Chemistry, , vol. 14, # 5 p. 1281 - 1283
反应条件
C36H35IrN2P(1+)*C32H12BF24(1-); potassium tert-butylate in diethylene glycol dimethyl ether T=60°C; 24 h; Inert atmosphere;
参考文献
Li, Jia-Qi; Andersson, Pher G.
Chemical Communications, 2013 , vol. 49, # 55 p. 6131 - 6133
反应条件
tri-ruthenium(0)dodecacarbonyl; cyclohexanone; N-phenyl-2-(dicyclohexylphosphino)pyrrol in cyclohexane T=140°C; 21 h; Inert atmosphereSchlenk techniqueAutoclave; Reagent/catalyst;
参考文献
Pingen, Dennis; Vogt, Dieter
Catalysis Science and Technology, 2014 , vol. 4, # 1 p. 47 - 52
反应条件
1-methyl-1H-imidazole; [2,2']bipyridinyl; 2,2,6,6-tetramethyl-piperidine-N-oxyl; copper(II) bis(trifluoromethanesulfonate); 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=60°C; 24 h; Molecular sieve;
参考文献
Green Chemistry, , vol. 14, # 5 p. 1281 - 1283
反应条件
tri-ruthenium(0)dodecacarbonyl; cyclohexanone; N-phenyl-2-(dicyclohexylphosphino)pyrrol in cyclohexane T=140°C; 21 h; Inert atmosphereSchlenk techniqueAutoclave; Reagent/catalyst;
参考文献
Pingen, Dennis; Vogt, Dieter
Catalysis Science and Technology, 2014 , vol. 4, # 1 p. 47 - 52
反应条件
1: With diisobutylaluminium hydride in diethyl ether; hexane
T=0°C; 1 h;
2: With sodium hydroxide; water in diethyl ether; hexane
T=20°C; 0.5 h;
3: With hydrogen; palladium 10 on activated carbon in ethanol
T=20°C; 89 h;
参考文献
Kyorin Pharmaceutical Co., Ltd.; Nisshin Pharma Inc.
Patent: EP1443046 A1, 2004 ;
Location in patent: Page 46 ;
EP 1443046 A1
反应条件
hydrogen; palladium on activated charcoal in methanol
T=20°C; 48 h;
参考文献
Patil, Nitin T.; Wu, Huanyou; Yamamoto, Yoshinori
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6577 - 6579
反应条件
hydrogen; palladium on activated charcoal in ethanol
Ambient temperature;
参考文献
Masuoka; Asako; Goto; Noguchi
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 1 p. 140 - 149
