4-氧代四氢呋喃-3-羧酸甲酯合成路线 （共 6 条）
参考文献
Sterling Winthrop Inc.
Patent: US5294612 A1, 1994 ;
反应条件
sodium hydride in dimethyl sulfoxide
T=0 - 20°C; 1 h;
参考文献
Tran, Joe A.; Chen, Caroline W.; Tucci, Fabio C.; Jiang, Wanlong; Fleck, Beth A.; Chen, Chen
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 1124 - 1130
反应条件
1: oxyacetic acid methyl ester With sodium hydride in diethyl ether
2: acrylic acid methyl ester in dimethyl sulfoxide
T=0 - 20°C; Michael addition; Dieckmann cyclization;
3: With hydrogenchloride in water; dimethyl sulfoxide
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/94400 A2, 2004 ;
Location in patent: Page 40 ;
WO 2004/094400 A2
反应条件
1: oxyacetic acid methyl ester With sodium hydride in diethyl ether
T=20°C; 2 h;
2: methyl acrylate in dimethyl sulfoxide
T=0 - 20°C; 1.25 h;
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2005/40109 A1, 2005 ;
Location in patent: Page/Page column 78-79 ;
WO 2005/040109 A1
反应条件
in diethyl ether; dimethyl sulfoxide
T=0 - 20°C; 1.75 h;
参考文献
Athersys, Inc.
Patent: US2006/9451 A1, 2006 ;
Location in patent: Page/Page column 19 ;
US 20060009451 A1
反应条件
sodium methylate in ethanol
参考文献
Sterling Winthrop Inc.
Patent: US5294612 A1, 1994 ;
