2-(2-甲氧基苯基)-4,4-二甲基-2-噁唑啉合成路线 （共 54 条）
反应条件
1: 1.) Mg / 1.) THF, 80 deg C, 0.5 h, 2.) THF, 40 deg C, 5 h
2: 50 percent / 6 N aq. HCl / 60 h / Heating
View Scheme
参考文献
Dorra, Michael; Gomann, Klaus; Guth, Michael; Kirmse, Wolfgang
Journal of Physical Organic Chemistry, 1996 , vol. 9, # 9 p. 598 - 610
反应条件
in tetrahydrofuran; pentane
T=-45°C; 3 h;
参考文献
Beak, Peter; Kerrick, Shawn T.; Gallagher, Donald J.
Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 10628 - 10636
反应条件
ammonium chloride; magnesium in tetrahydrofuran
参考文献
Eisai Co., Ltd.
Patent: US5554757 A1, 1996 ;
US 5554757 A
反应条件
in tetrahydrofuran
T=20°C; 2 h; Yield given;
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
magnesium in tetrahydrofuran; hexane; ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US5135938 A1, 1992 ;
反应条件
in tetrahydrofuran
20 h; Ambient temperature;
参考文献
Perchonock; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery; Kirchner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1145 - 1147
反应条件
magnesium
1.) THF, 2.) THF, RT, 20 h; Yield given;
参考文献
Perchonock; Uzinskas; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1442 - 1452
反应条件
magnesium in tetrahydrofuran
参考文献
SmithKline Beckman Corporation
Patent: US4730005 A1, 1988 ;
US 4730005 A
反应条件
magnesium
1.) THF, 2.) THF, RT, 20 h; Yield given;
参考文献
SmithKline Beecham Corporation
Patent: US5135938 A1, 1992 ;
Title/Abstract Full Text Show Details
SmithKline Beecham Corporation
Patent: US5143931 A1, 1992 ;
US 5143931 A
反应条件
in tetrahydrofuran
20 h; Ambient temperature;
参考文献
Perchonock; McCarthy; Erhard; Gleason; Wasserman; Muccitelli; DeVan; Tucker; Vickery; Kirchner
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1145 - 1147
