2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
magnesium 1.) ether, 2.) ether, reflux, 2 h; room temp., overnight; Yield given. Multistep reaction;
参考文献
Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 2 p. 185 - 200
反应条件
(i) Mg, BrCH2CH2Br, (ii) CdCl2, (iii) /BRN= 605303/; Multistep reaction;
参考文献
Spivey, Alan C.; Gripton, Christopher J. G.; Noban, Catherine; Parr, Nigel J.
Synlett, 2005 , # 14 art. no. D17105ST, p. 2167 - 2170
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / |Inert atmosphere; |Schlenk technique 1.2: 1 h / -78 °C / |Inert atmosphere; |Schlenk technique 2.1: pyridinium chlorochromate / dichloromethane / 1 h / 25 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Lafleur, Karine; Dong, Jing; Huang, Danzhi; Caflisch, Amedeo; Nevado, Cristina
Journal of Medicinal Chemistry, 2013 , vol. 56, # 1 p. 84 - 96
反应条件
iodine; magnesium in tetrahydrofuran Metallation; 0.5 h; Heating;
参考文献
Campos, Jesus; Espada, Maria F.; Lopez-Serrano, Joaquin; Carmona, Ernesto
Inorganic Chemistry, 2013 , vol. 52, # 11 p. 6694 - 6704
反应条件
tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine; Cy2NMe2 in 1,4-dioxane T=20°C; Heck coupling; 12 h; Title compound not separated from byproducts.;
参考文献
Littke; Fu
Journal of the American Chemical Society, 2001 , vol. 123, # 29 p. 6989 - 7000
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Luening, Ulrich; Mueller, Michael
Chemische Berichte, 1990 , vol. 123, p. 643 - 646
反应条件
1.1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 24 h / Reflux 2.1: potassium carbonate; potassium iodide / pentan-3-one / 48 h / Reflux 3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2.5 h / -78 °C 3.2: 3 h / 20 °C 3.3: pH Ca. 10 View Scheme
参考文献
NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
Patent: US2011/319620 A1, 2011 ;
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chemische Berichte, , vol. 123, p. 643 - 646
反应条件
copper(l) iodide; dimethylammonium 2,4-dichlorophenoxyacetate; potassium carbonate T=90°C; 48 h;
参考文献
Journal of the American Chemical Society, , vol. 120, # 48 p. 12459 - 12467
