2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
1: 1-bromo-2,6-dimethyl-benzene With iodine; magnesium in tetrahydrofuran
T=40°C; 0.333333 h;
2: acetaldehyde in tetrahydrofuran
1 h; Heating; Further stages.;
参考文献
Noji, Masahiro; Konno, Yosuke; Ishii, Keitaro
Journal of Organic Chemistry, 2007 , vol. 72, # 14 p. 5161 - 5167
反应条件
1: Mg; I2 / tetrahydrofuran / 0.5 h / Heating
2: tetrahydrofuran
View Scheme
参考文献
Reuvers,A.J.M. et al.
Tetrahedron, 1969 , vol. 25, p. 4455 - 4465
反应条件
potassium permanganate; water
Behandeln des Reaktionsprodukts mit Chlorwasserstoff enthaltendem Methanol;
参考文献
Coulson
Journal of the Chemical Society, 1937 , p. 1298,1304
反应条件
quinoline; 1,10-phenanthroline; tris-(o-tolyl)phosphine; copper(I) bromide in 1-methyl-pyrrolidin-2-one; quinoline
T=170°C; 16 h;
参考文献
Goossen, Lukas J.; Rudolphi, Felix; Oppel, Christoph; Rodriguez, Nuria
Angewandte Chemie - International Edition, 2008 , vol. 47, # 16 p. 3043 - 3045
反应条件
2-Me3Si-3-PPh2-1',2',3',4',5'-pentamethylferrocene; tris(dibenzylideneacetone)dipalladium (0)
T=20°C; Suzuki cross-coupling reaction; 24 h;
参考文献
Liu; Choi; Fu
Chemical Communications, 2001 , # 23 p. 2408 - 2409
反应条件
potassium phosphate in toluene
参考文献
Yale University
Patent: US6562989 B2, 2003 ;
反应条件
1: 1-bromo-2,6-dimethyl-benzene With magnesium in tetrahydrofuran
2: ortho-chlorotoluene With tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran
T=25°C; Kumada-Corriu cross-coupling; 24 h; Further stages.;
参考文献
Wolf, Christian; Xu, Hanhui
Journal of Organic Chemistry, 2008 , vol. 73, # 1 p. 162 - 167
反应条件
1: 1-bromo-2,6-dimethyl-benzene With magnesium in tetrahydrofuran
2: 1-bromo-2-methyl benzene With tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran
T=25°C; Kumada-Corriu cross-coupling; 15 h; Further stages.;
参考文献
Wolf, Christian; Xu, Hanhui
Journal of Organic Chemistry, 2008 , vol. 73, # 1 p. 162 - 167
反应条件
palladium diacetate; Cl- P(t-Bu)3CH(CH2CH2)2NMe2+; sodium carbonate in water; acetonitrile
T=20°C; Suzuki coupling;
参考文献
Shaughnessy, Kevin H.; Booth, Rebecca S.
Organic Letters, 2001 , vol. 3, # 17 p. 2757 - 2759
反应条件
1.1: 1,2-dimethoxy-ethane / 2 h
1.2: I2 / tetrahydrofuran / 3 h / 20 °C
2.1: 94 percent / Pd(OAc)2; Et3N; (2-MeC6H4)3P / acetonitrile / 24 h / Heating
3.1: 99 percent / 1 M aq. NaOH / dioxane / 2 h / 20 °C
4.1: H2 / 10 percent Pd/C / ethyl acetate / 70 °C / 3040 Torr
5.1: Et3N; DCC; HOBt / dimethylformamide / 5 h / 0 - 20 °C
6.1: conc. HCl / 8 h / Heating
6.2: H2O / pH 4 - 6
View Scheme
参考文献
Sasaki, Yusuke; Hirabuki, Mariko; Ambo, Akihiro; Ouchi, Hidekazu; Yamamoto, Yutaka
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 3 p. 327 - 329
