2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
dichloro bis(acetonitrile) palladium(II); caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in water
T=20°C; Sonogashira coupling; Inert atmosphereMicellar solution;
参考文献
Lipshutz, Bruce H.; Chung, David W.; Rich, Brian
Organic Letters, 2008 , vol. 10, # 17 p. 3793 - 3796
反应条件
tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine in hexane; toluene
T=20°C; Stille cross-coupling; 24 h;
参考文献
Littke, Adam F.; Schwarz, Lothar; Fu, Gregory C.
Journal of the American Chemical Society, 2002 , vol. 124, # 22 p. 6343 - 6348
反应条件
cBRIDP; bis(η3-allyl-μ-chloropalladium(II)); potassium hydroxide in water
T=20 - 50°C; 72 h; Inert atmosphereMicellar solution;
参考文献
Lipshutz, Bruce H.; Chung, David W.; Rich, Brian
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 11-12 p. 1717 - 1721
反应条件
2-[(dimethylamino)methyl]-1-thiophenolato-copper(I); caesium carbonate in 1-methyl-pyrrolidin-2-one
T=160°C; 6 h; Inert atmosphere;
参考文献
Sperotto, Elena; Van Klink, Gerard P.M.; De Vries, Johannes G.; Van Koten, Gerard
Tetrahedron, 2010 , vol. 66, # 46 p. 9009 - 9020
反应条件
n-butyllithium
1.) ether, hexane, reflux, overnight, 2.) THF, RT, overnight; Yield givenMultistep reaction;
参考文献
Van Der Boom, Milko E.; Liou, Shyh-Yeon; Ben-David, Yehoshoa; Gozin, Michael; Milstein, David
Journal of the American Chemical Society, 1998 , vol. 120, # 51 p. 13415 - 13421
反应条件
magnesium
1.) THF, -78 deg C, 30 min, 2.) reflux, 60 h; Yield given. Multistep reaction;
参考文献
Eisch, John J.; Shafii, Babak; Odom, Jerome D.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1990 , vol. 112, # 5 p. 1847 - 1853
反应条件
1: copper(I)iodide; dichlorobis(triphenylphosphine) palladium (II); PPh3 / various solvent(s) / 2 h / Heating
2: 1.94 g / Bu4NF / tetrahydrofuran; H2O / 1.5 h / 20 °C
View Scheme
参考文献
Panda, Jagannath; Virkler, Peter R.; Detty, Michael R.
Journal of Organic Chemistry, 2003 , vol. 68, # 5 p. 1804 - 1809
反应条件
tris(dibenzylideneacetone)dipalladium (0); Ti-N complexes; (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate in toluene
T=90°C; 8 h;
参考文献
Hori; Mori
Journal of the American Chemical Society, 1998 , vol. 120, # 30 p. 7651 - 7652
反应条件
tris-(dibenzylideneacetone)dipalladium(0); trineopentylphosphine; sodium t-butanolate in toluene
T=80°C; Buchwald-Hartwig Coupling; 1 h; Inert atmosphereGlovebox;
参考文献
Raders, Steven M.; Moore, Jane N.; Parks, Jacquelynn K.; Miller, Ashley D.; Leissing, Thomas M.; Kelley, Steven P.; Rogers, Robin D.; Shaughnessy, Kevin H.
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 4649 - 4664
反应条件
sodium t-butanolate; palladium diacetate in toluene
18 h; Heating;
参考文献
Bedford, Robin B.; Betham, Michael
Tetrahedron Letters, 2007 , vol. 48, # 51 p. 8947 - 8950
