2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
trans-dichloro(1,3-bis-(2,6-diisopentylphenyl)imidazolylidinium)(3-chloro-pyridine); potassium tert-butylate in tert-butyl alcohol
T=65°C; Suzuki-Miyaura coupling; Inert atmosphereMolecular sieve;
参考文献
Organ, Michael G.; Calimsiz, Seluk; Sayah, Mahmoud; Hoi, Ka Hou; Lough, Alan J.
Angewandte Chemie, International Edition, 2009 , vol. 48, # 13 p. 2383 - 2387
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With Pd-PEPPSI-IPent; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=23°C; Negishi coupling; 8 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
tripotassium phosphate monohydrate; R-Phos; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran
T=50°C; Suzuki coupling; 4 h; Inert atmosphere;
参考文献
Hoshi, Takashi; Saitoh, Ippei; Nakazawa, Taichi; Suzuki, Toshio; Sakai, Jun-Ichi; Hagiwara, Hisahiro
Journal of Organic Chemistry, 2009 , vol. 74, # 10 p. 4013 - 4016
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With Pd-PEPPSI-IPent; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With PEPPSITM-IPr; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
potassium phosphate; PdCl(NH2C6H4C6H4)(C6H4(CH3)4O3PC6H5); water in 2-methyl tetrahydrofuran
T=60°C; 72 h; Inert atmosphere;
参考文献
Schmink, Jason R.; Krska, Shane W.
Journal of the American Chemical Society, 2011 , vol. 133, # 49 p. 19574 - 19577
反应条件
palladium diacetate in water; N,N-dimethyl-formamide
T=20°C; 5 h;
参考文献
Yamamoto, Yasunori; Takizawa, Miho; Yu, Xiao-Qiang; Miyaura, Norio
Angewandte Chemie - International Edition, 2008 , vol. 47, # 5 p. 928 - 931
反应条件
potassium carbonate in water
T=80°C; Suzuki coupling; 3 h;
参考文献
Ohtaka, Atsushi; Kono, Yuki; Teratani, Takuto; Fujii, Syuji; Matsuzawa, Soichiro; Nakamura, Yoshinobu; Nomura, Ryoki
Catalysis Letters, 2011 , vol. 141, # 8 p. 1097 - 1103
反应条件
1: NBS
2: 70 percent / Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / Heating
View Scheme
参考文献
Harvey, Ronald G.; Lim, Keunpoong; Dai, Qing
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1372 - 1373
