2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
1: N-bromosuccinimide / CCl4
View Scheme
参考文献
Poleschner, Helmut; Seppelt, Konrad
Chemistry - A European Journal, 2004 , vol. 10, # 24 p. 6565 - 6574
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) a) 1 h, b) from -78 deg C to RT, 4.5 h
2: 79 percent / pyridine / 4 h / Heating
3: AlCl3 / CS2 / 4 h / Ambient temperature
4: 15 percent / conc. H2SO4 / 4 h / 90 °C
View Scheme
参考文献
Sheridan; Lemon; Frankish; McArdle; Higgins; James; Bhandari
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 7 p. 603 - 608
反应条件
1: NO2/HNO3, Ac2O
2: H2 / PtO2
View Scheme
参考文献
Meltzer,P.C.; Staskun,B.
Tetrahedron, 1977 , vol. 33, p. 2965 - 2967
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
参考文献
Baker, Robert W.; Foulkes, Michael A.; Griggs, Michael; Nguyen, Bao N.
Tetrahedron Letters, 2002 , vol. 43, # 51 p. 9319 - 9322
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in benzene
24 h; Heatingirradiation;
参考文献
Harvey, Ronald G.; Dai, Qing; Ran, Chongzhao; Penning, Trevor M.
Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 2024 - 2032
反应条件
tris(dibenzylideneacetone)dipalladium (0); di-tert-butylneopentylphosphonium tetrafluoroborate; sodium t-butanolate in toluene
T=50°C; Hartwig-Buchwald amination;
参考文献
Hill, Lensey L.; Moore, Lucas R.; Huang, Rongeai; Craciun, Raluca; Vincent, Andrew J.; Dixon, David A.; Chou, Joe; Woltermann, Christopher J.; Shaughnessy, Kevin H.
Journal of Organic Chemistry, 2006 , vol. 71, # 14 p. 5117 - 5125
反应条件
1: 54 percent / PPh3; Et3N / Pd(OAc)2 / dimethylformamide
2: H2 / Pd black / ethanol
View Scheme
参考文献
Nakamura, Mitsuhiro; Mamino, Masashi; Masaki, Mizuki; Maki, Shojiro; Matsui, Ryo; Kojima, Satoshi; Hirano, Takashi; Ohmiya, Yoshihiro; Niwa, Haruki
Tetrahedron Letters, 2005 , vol. 46, # 1 p. 53 - 56
反应条件
1: 54 percent / PPh3; Et3N / Pd(OAc)2 / dimethylformamide
2: H2 / Pd black / ethanol
3: 84 percent / LiHMDS / tetrahydrofuran
View Scheme
参考文献
Nakamura, Mitsuhiro; Mamino, Masashi; Masaki, Mizuki; Maki, Shojiro; Matsui, Ryo; Kojima, Satoshi; Hirano, Takashi; Ohmiya, Yoshihiro; Niwa, Haruki
Tetrahedron Letters, 2005 , vol. 46, # 1 p. 53 - 56
反应条件
1: 54 percent / PPh3; Et3N / Pd(OAc)2 / dimethylformamide
2: H2 / Pd black / ethanol
3: 84 percent / LiHMDS / tetrahydrofuran
4: 95 percent / DIBAH / toluene
View Scheme
参考文献
Nakamura, Mitsuhiro; Mamino, Masashi; Masaki, Mizuki; Maki, Shojiro; Matsui, Ryo; Kojima, Satoshi; Hirano, Takashi; Ohmiya, Yoshihiro; Niwa, Haruki
Tetrahedron Letters, 2005 , vol. 46, # 1 p. 53 - 56
反应条件
1: 54 percent / PPh3; Et3N / Pd(OAc)2 / dimethylformamide
2: H2 / Pd black / ethanol
3: 84 percent / LiHMDS / tetrahydrofuran
4: 95 percent / DIBAH / toluene
5: 83 percent / MnO2 / CH2Cl2
View Scheme
参考文献
Nakamura, Mitsuhiro; Mamino, Masashi; Masaki, Mizuki; Maki, Shojiro; Matsui, Ryo; Kojima, Satoshi; Hirano, Takashi; Ohmiya, Yoshihiro; Niwa, Haruki
Tetrahedron Letters, 2005 , vol. 46, # 1 p. 53 - 56
