2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
1: 5.7 percent / Mg / diethyl ether
2: Mg / diethyl ether
3: Pd/C
View Scheme
参考文献
Melzer, Peter; Kurreck, Harry; Kieslich, Wolfgang
Chemische Berichte, 1982 , vol. 115, # 11 p. 3597 - 3609
反应条件
1: 1.) THF, 2.) -55 deg C to -70 deg C, 2h, RT, 20h, THF
2: 87 percent / PCl3 / diethyl ether / 3 h
3: 1.) sodium-potassium alloy / 1.) THF, 30 min, 2.) RT, 20h
4: 70 percent / PCl3 / diethyl ether
5: 83 percent / DBU / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Knaap, Th.A. van der; Klebach, Th.C.; Visser, F.; Bickelhaupt, F.; Ros, P.; et al.
Tetrahedron, 1984 , vol. 40, # 4 p. 765 - 776
反应条件
magnesium
1.) THF, 50 deg C, 1.5 h; 2.) THF, -78 deg C to RT; Yield given. Multistep reaction;
参考文献
Shutske, Gregory M.
Journal of Organic Chemistry, 1984 , vol. 49, # 1 p. 180 - 183
反应条件
1: 1.) Mg / 1.) THF, 50 deg C, 1.5 h; 2.) THF, -78 deg C to RT
2: 12 percent / H2NOH*HCl / pyridine / 40 h / Heating
View Scheme
参考文献
Shutske, Gregory M.
Journal of Organic Chemistry, 1984 , vol. 49, # 1 p. 180 - 183
反应条件
zinc(II) chloride
30 h; Ambient temperature;
参考文献
Schirch,P.F.; Boekelheide,V.
Journal of the American Chemical Society, 1981 , vol. 103, p. 6873
反应条件
sulfuric acid
3 h; Heating;
参考文献
Sun, Zhiyuan; Hosmane, Ramachandra S.; Tadros, Maher; Guha, Shekhar; Chen, Wenpeng; Chen, Jar-Mo
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1819 - 1828
反应条件
Pd(TPPMS)2Cl2; diphenylphosphinobenzene-3-sulfonic acid sodium salt; octadecyl-trimethylammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene in water
20 h; Heating;
参考文献
Park, Kyungho; Bae, Goun; Park, Ahbyeol; Kim, Yong; Choe, Jaehoon; Song, Kwang Ho; Lee, Sunwoo
Tetrahedron Letters, 2011 , vol. 52, # 5 p. 576 - 580
反应条件
potassium carbonate; i-Pr2NPPh2; palladium diacetate in tetrahydrofuran
T=65°C; 12 h;
参考文献
Zhang, Weiwei; Wu, Huayue; Liu, Zhiqing; Zhong, Ping; Zhang, Lin; Huang, Xiaobo; Cheng, Jiang
Chemical Communications, 2006 , # 46 p. 4826 - 4828
反应条件
bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide
T=110°C; 3 h;
参考文献
Park, Kyungho; Bae, Goun; Moon, Jeongju; Choe, Jaehoon; Song, Kwang Ho; Lee, Sunwoo
Journal of Organic Chemistry, 2010 , vol. 75, # 18 p. 6244 - 6251
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 1209228/
2: aq. HBr
3: aq. ethanol
4: aq. H2SO4
5: SOCl2
6: (i) Et2O, (ii) HCl
7: benzene
View Scheme
参考文献
Loefgren,N. et al.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 1252 - 1261
