2-溴-1,3-二甲苯合成路线 （共 189 条）
参考文献
Coulson
Journal of the Chemical Society, 1937 , p. 1298,1304
反应条件
sulfuric acid; nitric acid
T=-10°C; 1 h;
参考文献
F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James; LEE, Wendy; MATHIEU, Simon; RUDOLPH, Joachim
Patent: WO2013/26914 A1, 2013 ;
Location in patent: Page/Page column 170 ;
WO 2013/026914 A1
反应条件
1.1: sulfuric acid; nitric acid / 1 h / -10 °C
2.1: pyrrolidine / 1,4-dioxane / 18 h / 100 °C / |Inert atmosphere
2.2: 4 h / 110 °C
View Scheme
参考文献
SAREUM LIMITED; READER, John Charles
Patent: WO2013/117522 A1, 2013 ;
反应条件
tert.-butyl lithium in pentane
T=-78 - 20°C;
参考文献
Knorr, Rudolf; Pires, Claudio; Behringer, Claudia; Menke, Thomas; Freudenreich, Johannes; Rossmann, Eva C.; Boehrer, Petra
Journal of the American Chemical Society, 2006 , vol. 128, # 46 p. 14845 - 14853
反应条件
1: With n-butyllithium in diethyl ether; hexane
T=-78°C; 1.5 h; Inert atmosphere;
2: With copper (I) cyanide in diethyl ether; hexane
T=20°C; Inert atmosphere;
3: With DAQ in diethyl ether; hexane
4 h; Inert atmosphere;
参考文献
Shukla, Ruchi; Rathore, Rajendra
Synthesis, 2008 , # 23 art. no. M03908S, p. 3769 - 3774
反应条件
palladium diacetate; BIPHEP; copper(l) chloride in N,N-dimethyl-formamide
T=80°C; 14 h; Inert atmosphere;
参考文献
Li, Gao-Qiang; Yamamoto, Yasunori; Miyaura, Norio
Synlett, 2011 , # 12 p. 1769 - 1773
反应条件
[Pd(1,3-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene)(cinnamyl)Cl]; potassium 2-methyl-2-butoxide in 1,4-dioxane
T=110°C; Buchwald-Hartwig Coupling; 12 h; Inert atmosphereSealed tube;
参考文献
Bastug, Gulluzar; Nolan, Steven P.
Organometallics, 2014 , vol. 33, # 5 p. 1253 - 1258
反应条件
1: With magnesium in tetrahydrofuran
T=20°C; 3 h; Inert atmosphere;
2: With synthetic air; cobalt(II) chloride in tetrahydrofuran
T=0°C; 3 h; Inert atmosphere;
参考文献
Mayer, Matthias; Czaplik, Waldemar Maximilian; Jacobi Von Wangelin, Axel
Synlett, 2009 , # 18 p. 2919 - 2923
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With Pd-PEPPSI-IPent; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium(0); zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
