2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
1: 2,4,6-trimethylphenylmagnesium bromide With PEPPSITM-IPr; zinc(II) chloride in tetrahydrofuran
T=23°C; 0.333333 h; Inert atmosphere;
2: 1-bromo-2,6-dimethyl-benzene in tetrahydrofuran
T=70°C; 2.5 h; Inert atmosphere;
参考文献
Calimsiz, Selcuk; Sayah, Mahmoud; Mallik, Debasis; Organ, Michael G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 11 p. 2014 - 2017
反应条件
C47H50ClN2P2Pd; cesium fluoride in tetrahydrofuran
Suzuki coupling; 20 h; RefluxInert atmosphere;
参考文献
Snead, David R.; Inagaki, Sebastien; Abboud, Khalil A.; Hong, Sukwon
Organometallics, 2010 , vol. 29, # 7 p. 1729 - 1739
反应条件
tetrabutyl ammonium fluoride; palladium dichloride; tri-cyclo-hexyl-phosphine in water; dimethyl sulfoxide
T=80°C; 4 h;
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
potassium fluoride; palladium diacetate in tetrahydrofuran
参考文献
Buchwald, Stephen L.; Huang, Xiaohua; Zim, Danilo
Patent: US2004/171833 A1, 2004 ;
反应条件
palladium diacetate; caesium carbonate; triphenylphosphine in o-xylene
6 h; Heating;
参考文献
Terao; Wakui; Satoh; Miura; Nomura
Journal of the American Chemical Society, 2001 , vol. 123, # 42 p. 10407 - 10408
反应条件
tetrabutyl ammonium fluoride; bis(dibenzylideneacetone)-palladium(0); 2-dicyclohexylphosphino-1,1'-biphenyl in tetrahydrofuran
T=120°C; 0.166667 h; microwave irradiation;
参考文献
Seganish, W. Michael; DeShong, Philip
Organic Letters, 2004 , vol. 6, # 23 p. 4379 - 4381
反应条件
cesium fluoride in water; N,N-dimethyl-formamide
T=40°C; Stille coupling; 12 h;
参考文献
Wu, Lei; Li, Zhi-Wei; Zhang, Feng; He, Yan-Mei; Fan, Qing-Hua
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 6 p. 846 - 862
反应条件
tetrabutyl ammonium fluoride; tris-(o-tolyl)phosphine; dichloro bis(acetonitrile) palladium(II)
T=80°C; Hiyama cross-coupling reaction; 0.75 h;
参考文献
Li, Jin-Heng; Deng, Chen-Liang; Xie, Ye-Xiang
Synthesis, 2006 , # 6 p. 969 - 974
反应条件
palladium diacetate; tri-cyclo-hexyl-phosphine in ethylene glycol dimethyl ether
T=20°C; 3 h;
参考文献
Ku, Shih-Lun; Hui, Xin-Ping; Chen, Chien-An; Kuo, Yi-Ying; Gau, Han-Mou
Chemical Communications, 2007 , # 37 p. 3847 - 3849
反应条件
tetrabutyl ammonium fluoride; triphenylphosphine; palladium diacetate in tetrahydrofuran; N,N-dimethyl-formamide
Heating;
参考文献
Riggleman, Shaundra; DeShong, Philip
Journal of Organic Chemistry, 2003 , vol. 68, # 21 p. 8106 - 8109
