2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
1: diallyl(diphenyl)silane With tetrabutyl ammonium fluoride in water; dimethyl sulfoxide
T=20°C; 1 h;
2: 1-bromo-2,6-dimethyl-benzene With tri-cyclo-hexyl-phosphine; palladium dichloride in water; dimethyl sulfoxide
T=80°C; 24 h;
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
tetrabutyl ammonium fluoride; triphenylphosphine; palladium diacetate in tetrahydrofuran; N,N-dimethyl-formamide
T=83°C; 23.5 h;
参考文献
Mowery; DeShong
Organic letters, 1999 , vol. 1, # 13 p. 2137 - 2140
反应条件
2-phenyl-1H-imidazole; nickel dichloride in tetrahydrofuran
T=50 - 60°C; Kumada Cross-Coupling; 3 h; Inert atmosphereSchlenk technique;
参考文献
Iwamoto, Ryo; Hayashi, Masahiko
Heterocycles, 2012 , vol. 86, # 1 p. 713 - 718
反应条件
1: 8.0 g / potassium permanganate; Celite / 2-methyl-propan-2-ol; H2O / 16 h / Heating
2: 6.5 g / H2SO4 / methanol / 16 h / Heating
View Scheme
参考文献
ANACOR PHARMACEUTICALS, INC.; ZHOU, Huchen; DING, Dazhong; ZHOU, Yasheen; ZHANG, Yong-Kang; PLATTNER, Jacob J.
Patent: WO2011/22337 A1, 2011 ;
反应条件
potassium permanganate; water
Behandeln des Reaktionsprodukts mit Chlorwasserstoff enthaltendem Methanol;
参考文献
Coulson
Journal of the Chemical Society, 1937 , p. 1298,1304
反应条件
potassium hydroxide; Pd[P(t-Bu3)]2; N-hexadecyl-N,N,N-trimethylammonium bromide in water; toluene
T=90°C; 6 h;
参考文献
Kuwano, Ryoichi; Utsunomiya, Masaru; Hartwig, John F.
Journal of Organic Chemistry, 2002 , vol. 67, # 18 p. 6479 - 6486
反应条件
N-methyl-pyrrolidine; copper(l) iodide
T=160°C; 60 h;
参考文献
Van Der Boom, Milko E.; Ben-David, Yehoshoa; Milstein, David
Journal of the American Chemical Society, 1999 , vol. 121, # 28 p. 6652 - 6656
反应条件
hydrogenchloride; ammonium hydroxide; ammonia; calcium carbonate; copper(I) bromide
参考文献
Chevron Research Company
Patent: US4340757 A1, 1982 ;
反应条件
n-butyllithium; sulfur
1.) hexane, diethyl ether, reflux, 2 h then room t., 15 h; 2.) thf, 2 h, room t. then room t., 15 h; Yield given. Multistep reaction;
参考文献
Dupont, Jairton; Beydoun, Nohma; Pfeffer, Michel
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1989 , p. 1715 - 1720
