2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
CyPF-tBu; palladium diacetate; sodium t-butanolate in ethylene glycol dimethyl ether T=110°C; 2 h; Inert atmosphere;
参考文献
Fernandez-Rodriguez, Manuel A.; Hartwig, John F.
Journal of Organic Chemistry, 2009 , vol. 74, # 4 p. 1664 - 1672
反应条件
palladium diacetate; Cl- P(t-Bu)3CH(CH2CH2)2NMe2+; sodium carbonate in water; acetonitrile T=20°C; Suzuki coupling;
参考文献
Organic Letters, , vol. 3, # 17 p. 2757 - 2759
反应条件
potassium hydroxide; water; polyaniline-supported palladium in 1,4-dioxane T=100°C; 12 h;
参考文献
Gallon, Benjamin J.; Kojima, Robert W.; Kaner, Richard B.; Diaconescu, Paula L.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 38 p. 7251 - 7254
反应条件
1: With magnesium in tetrahydrofuran T=20°C; 3 h; Inert atmosphere; 2: With synthetic air; cobalt(II) chloride in tetrahydrofuran T=0°C; 3 h; Inert atmosphere;
参考文献
Synlett, , # 18 p. 2919 - 2923
反应条件
1: 49 percent / NBS; (PhCO2)2 / CCl4 2: 82 percent / ethanol View Scheme
参考文献
Schuisky, Peter; Federsel, Hans-Juergen; Tian, Wei
Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5503 - 5514
反应条件
1: 49 percent / NBS; (PhCO2)2 / CCl4 2: 82 percent / ethanol 3: 60 percent / conc. H2SO4 4: 100 percent / LAH / diethyl ether View Scheme
参考文献
Baker, Robert W.; Foulkes, Michael A.; Griggs, Michael; Nguyen, Bao N.
Tetrahedron Letters, 2002 , vol. 43, # 51 p. 9319 - 9322
反应条件
(i) CdCl2, (ii) /BRN= 385668/; Multistep reaction;
参考文献
Reuvers,A.J.M. et al.
Tetrahedron, 1969 , vol. 25, p. 4455 - 4465
反应条件
N-bromosuccinmide in acetonitrile T=20°C; Inert atmosphere;
参考文献
PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas
Patent: WO2012/139775 A1, 2012 ;
Location in patent: Page/Page column 36 ;
WO 2012/139775 A1
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in benzene 24 h; Heatingirradiation;
参考文献
Harvey, Ronald G.; Dai, Qing; Ran, Chongzhao; Penning, Trevor M.
Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 2024 - 2032
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in benzene 24 h; Heatingirradiation;
参考文献
Harvey, Ronald G.; Dai, Qing; Ran, Chongzhao; Penning, Trevor M.
Journal of Organic Chemistry, 2004 , vol. 69, # 6 p. 2024 - 2032
