2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / dichloromethane / Reflux 2: ethanol; water / Reflux 3: sulfuric acid / 140 °C View Scheme
参考文献
Schuisky, Peter; Federsel, Hans-Juergen; Tian, Wei
Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5503 - 5514
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 1209228/ 2: aq. HBr View Scheme
参考文献
Loefgren,N. et al.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 1252 - 1261
反应条件
1: With N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 3 h; Reflux; 2: With water; calcium carbonate in 1,4-dioxane 72 h; Reflux;
参考文献
Sun, Liang; Veith, Jean M.; Pera, Paula; Bernacki, Ralph J.; Ojima, Iwao
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 19 p. 7101 - 7112
反应条件
1: 1-bromo-2,6-dimethyl-benzene With ethyl bromide; magnesium in diethyl ether Grignard reaction; Inert atmosphereReflux; 2: carbon dioxide in diethyl ether T=20°C; Grignard reaction; Inert atmosphere;
参考文献
Shiina, Isamu; Miyao, Ryo
Heterocycles, 2008 , vol. 76, # 2 p. 1313 - 1328
反应条件
1: (i) Mg, BrCH2CH2Br, (ii) /BRN= 1733899/ 2: aq. KMnO4, NaOH View Scheme
参考文献
Beard,W.Q. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2310 - 2316
反应条件
sodium carbonate; palladium diacetate T=160°C; 16 h;
参考文献
Schareina, Thomas; Zapf, Alexander; Beller, Matthias
Chemical Communications, 2004 , # 12 p. 1388 - 1389
反应条件
1-(n-1-butyl)-imidazole; copper(l) iodide in toluene T=160°C; 16 h;
参考文献
Schareina, Thomas; Zapf, Alexander; Maegerlein, Wolfgang; Mueller, Nikolaus; Beller, Matthias
Chemistry - A European Journal, 2007 , vol. 13, # 21 p. 6249 - 6254
反应条件
in 1-methyl-pyrrolidin-2-one; water T=200°C; P=10343 Torr; 0.166667 h; microwave irradiation;
参考文献
Arvela, Riina K.; Leadbeater, Nicholas E.
Journal of Organic Chemistry, 2003 , vol. 68, # 23 p. 9122 - 9125
反应条件
N,N,N',N,-tetramethylethylenediamine; palladium diacetate; sodium carbonate; 1,2-bis-(diphenylphosphino)ethane; potassium iodide in N,N-dimethyl-formamide T=130°C; 22 h; Inert atmosphere;
参考文献
Zheng, Shuyan; Yu, Chunhui; Shen, Zhengwu
Organic Letters, 2012 , vol. 14, # 14 p. 3644 - 3647
反应条件
in 1-methyl-pyrrolidin-2-one Reflux;
参考文献
Zhang, Line; Ang, Gim Yean; Chiba, Shunsuke
Organic Letters, 2011 , vol. 13, # 7 p. 1622 - 1625
