2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
1.1: 1,2-dimethoxy-ethane / 2 h 1.2: I2 / tetrahydrofuran / 3 h / 20 °C 2.1: 94 percent / Pd(OAc)2; Et3N; (2-MeC6H4)3P / acetonitrile / 24 h / Heating 3.1: 99 percent / 1 M aq. NaOH / dioxane / 2 h / 20 °C 4.1: H2 / 10 percent Pd/C / ethyl acetate / 70 °C / 3040 Torr 5.1: Et3N; DCC; HOBt / dimethylformamide / 5 h / 0 - 20 °C 6.1: conc. HCl / 8 h / Heating 6.2: H2O / pH 4 - 6 View Scheme
参考文献
Sasaki, Yusuke; Hirabuki, Mariko; Ambo, Akihiro; Ouchi, Hidekazu; Yamamoto, Yutaka
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 3 p. 327 - 329
反应条件
1: AlCl3 / CS2 / 3 h / 0 °C 2: 60 percent / conc. H2SO4 / 1 h / 90 °C View Scheme
参考文献
Sheridan; Lemon; Frankish; McArdle; Higgins; James; Bhandari
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 7 p. 603 - 608
反应条件
tetrabutylammomium bromide; caesium carbonate; tris(dibenzylideneacetone)dipalladium (0) in tetrahydrofuran; toluene T=20°C; Suzuki-Miyaura reaction; 16 h;
参考文献
Dhudshia, Bhartesh; Thadani, Avinash N.
Chemical Communications, 2006 , vol. 6, # 6 p. 668 - 670
反应条件
potassium carbonate; cyclopallated ferrocenylimine c in water; N,N-dimethyl-formamide T=110°C; Suzuki cross-coupling reaction; 10 h;
参考文献
Zhang, Jinli; Zhao, Liang; Song, Maoping; Mak, Thomas C.W.; Wu, Yangjie
Journal of Organometallic Chemistry, 2006 , vol. 691, # 6 p. 1301 - 1306
反应条件
1: With isopropylmagnesium chloride in tetrahydrofuran T=0°C; Inert atmosphere; 2: With methanol in tetrahydrofuran Kinetics; ConcentrationTime;
参考文献
Organic Letters, , vol. 14, # 10 p. 2602 - 2605
反应条件
sulfuric acid 3 h; Heating;
参考文献
Sun, Zhiyuan; Hosmane, Ramachandra S.; Tadros, Maher; Guha, Shekhar; Chen, Wenpeng; Chen, Jar-Mo
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1819 - 1828
反应条件
1: 1-bromo-2,6-dimethyl-benzene With magnesium in tetrahydrofuran T=20 - 50°C; 3 h; Inert atmosphere; 2: boric acid trimethyl ester in tetrahydrofuran T=-78 - 20°C; Inert atmosphere;
参考文献
Tu, Tao; Sun, Zheming; Fang, Weiwei; Xu, Mizhi; Zhou, Yunfei
Organic Letters, 2012 , vol. 14, # 16 p. 4250 - 4253
反应条件
1: BuLi 2: Acid hydrolysis View Scheme
参考文献
Molander, Gary A.; Trice, Sarah L. J.; Kennedy, Steven M.; Dreher, Spencer D.; Tudge, Matthew T.
Journal of the American Chemical Society, 2012 , vol. 134, # 28 p. 11667 - 11673
反应条件
1: 1-bromo-2,6-dimethyl-benzene With n-butyllithium; isopropylmagnesium chloride in tetrahydrofuran; hexane T=0 - 5°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0°C; 1 h; Further stages.;
参考文献
Gallou, Fabrice; Haenggi, Ruedi; Hirt, Hans; Marterer, Wolfgang; Schaefer, Frank; Seeger-Weibel, Manuela
Tetrahedron Letters, 2008 , vol. 49, # 34 p. 5024 - 5027
反应条件
triethylsilane; C23H42Cl2P2Pd; sodium carbonate in N,N-dimethyl-formamide T=140°C; P=11251.1 Torr; 24 h; Inert atmosphereAutoclave; Reagent/catalyst; chemoselective reaction;
参考文献
Organic Process Research and Development, , vol. 12, # 4 p. 566 - 574
