2-溴-1,3-二甲苯合成路线 （共 189 条）
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 102378/ 2: SOCl2 / benzene 3: N2H4*H2O / propan-1-ol / Heating View Scheme
参考文献
Bream,J.B. et al.
Journal of Medicinal Chemistry, 1970 , vol. 13, # 6 p. 1051 - 1057
反应条件
(i) Mg, Et2O, (ii) /BRN= 102378/; Multistep reaction;
参考文献
Ng; McMorris
Canadian Journal of Chemistry, 1984 , vol. 62, # 10 p. 1945 - 1953
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 102378/ 2: SOCl2 / benzene View Scheme
参考文献
Bream,J.B. et al.
Journal of Medicinal Chemistry, 1970 , vol. 13, # 6 p. 1051 - 1057
反应条件
1: 1-bromo-2,6-dimethyl-benzene With magnesium; ethylene dibromide in tetrahydrofuran Heating; 2: 1-Bromonaphthalene With bis(acetylacetonate)nickel(II) in tetrahydrofuran T=40°C;
参考文献
Ting, Yuhua; Lai, Yee-Hing
Journal of the American Chemical Society, 2004 , vol. 126, # 3 p. 909 - 914
反应条件
tripotassium phosphate monohydrate; R-Phos; bis(dibenzylideneacetone)-palladium(0) in 1,4-dioxane T=100°C; Suzuki coupling; 0.5 h; Inert atmosphere;
参考文献
Hoshi, Takashi; Saitoh, Ippei; Nakazawa, Taichi; Suzuki, Toshio; Sakai, Jun-Ichi; Hagiwara, Hisahiro
Journal of Organic Chemistry, 2009 , vol. 74, # 10 p. 4013 - 4016
反应条件
1: 1-bromo-2,6-dimethyl-benzene With magnesium in tetrahydrofuran HeatingInert atmosphere; 2: 2,4,6-tribromo-1-iodobenzene in tetrahydrofuran T=65°C; 4 h; Inert atmosphere;
参考文献
Stoll, Ragnar S.; Peters, Maike V.; Kuhn, Andreas; Hecht, Stefan; Heiles, Sven; Thiele, Christina M.; Goddard, Richard; Buehl, Michael
Journal of the American Chemical Society, 2009 , vol. 131, # 1 p. 357 - 367
反应条件
sodium t-butanolate; palladium diacetate in 1,4-dioxane T=100°C; 18 h;
参考文献
Murata, Miki; Buchwald, Stephen L.
Tetrahedron, 2004 , vol. 60, # 34 p. 7397 - 7403
参考文献
Wyeth
Patent: US2003/144282 A1, 2003 ;
反应条件
C27H50Cl2P2Pd; potassium carbonate in 1-methyl-pyrrolidin-2-one T=120°C; P=1500.15 Torr; 24 h; Inert atmosphereAutoclave; Reagent/catalyst; chemoselective reaction;
参考文献
Organic Process Research and Development, , vol. 12, # 4 p. 566 - 574
反应条件
1: (i) Mg, (ii) /BRN= 1900390/ View Scheme
参考文献
Newman,M.S.; Leegwater,A.L.
Journal of the American Chemical Society, 1968 , vol. 90, p. 4410 - 4413
