2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
1: 99 percent / 1,3-bis(2,6-diisopropylphenyl)imidazolium chloride; Pd(dba)2; t-BuOK / dioxane / 10 h / 80 °C 2: 87 percent / Acid hydrolysis 3: 92 percent / formic acid / methanol; H2O / 3 h / 20 °C 4: 97 percent / NaBH4 / tetrahydrofuran; methanol / 2 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 23 p. 7729 - 7737
反应条件
CPhos; palladium diacetate in tetrahydrofuran T=0 - 20°C; Negishi coupling reaction; Inert atmosphere;
参考文献
Han, Chong; Buchwald, Stephen L.
Journal of the American Chemical Society, 2009 , vol. 131, p. 7532 - 7533
反应条件
Pd-PEPPSI-IPent in tetrahydrofuran; toluene T=0 - 20°C; Negishi coupling reaction; 3 h; Inert atmosphere;
参考文献
Alimsiz, Seluk; Organ, Michael G.
Chemical Communications, 2011 , vol. 47, # 18 p. 5181 - 5183
参考文献
Bourgeois
Chemische Berichte, 1895 , vol. 28, p. 2319
Recueil des Travaux Chimiques des Pays-Bas, 1899 , vol. 18, p. 433
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: 4-chlorobenzaldehyde in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 3: With iodine; potassium carbonate in tert-butyl alcohol 18 h; Reflux;
参考文献
Ushijima, Sousuke; Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 5 p. 1436 - 1442
反应条件
potassium carbonate; [Pd(C3H5)Cl]2/Tedicyp complex in xylene T=130°C; Suzuki reaction; 20 h;
参考文献
Kondolff, Isabelle; Doucet, Henri; Santelli, Maurice
Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 1 p. 109 - 118
反应条件
palladium diacetate; tris-(o-tolyl)phosphine in toluene T=20°C; 5 h; Inert atmosphere;
参考文献
Chen, Xu; Zhou, Lingmin; Li, Yimei; Xie, Tao; Zhou, Shuangliu
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 230 - 239
反应条件
1: para-bromotoluene; 2-Bromo-1,3,5-trimethyl-benzene With magnesium in tetrahydrofuran 2 h; 2: 1,3-dichloro-2-iodobenzene in tetrahydrofuran Hart reaction; 3 h; Heating; 3: With iodine in tetrahydrofuran T=20°C;
参考文献
Toyota, Shinji; Yanagihara, Takashi; Yoshida, Yukihiro; Goichi, Michio
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 7 p. 1351 - 1353
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium carbonate in tetrahydrofuran; water T=80°C; Suzuki-Miyaura Coupling; 48 h; Inert atmosphereSealed tube;
参考文献
St. Denis, Jeffrey D.; Scully, Conor C. G.; Lee, C. Frank; Yudin, Andrei K.
Organic Letters, 2014 , vol. 16, # 5 p. 1338 - 1341
反应条件
sodium hydroxide; potassium permanganate 8 h; Heating;
参考文献
Holy, Petr; Zavada, Jiri; Zezula, Josef; Cisarva, Ivana; Podlaha, Jaroslav
Collection of Czechoslovak Chemical Communications, 2001 , vol. 66, # 5 p. 820 - 832
