2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With tert.-butyl lithium in tetrahydrofuran; pentane T=-78 - -20°C; 1 h; Inert atmosphere; 2: With copper(l) chloride in tetrahydrofuran; pentane T=-78°C; 1 h; Inert atmosphere; 3: Bn2N-OBz in tetrahydrofuran; pentane T=20°C; 4 h; Inert atmosphere;
参考文献
Matsuda, Naoki; Hirano, Koji; Satoh, Tetsuya; Miura, Masahiro
Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3642 - 3645
反应条件
1: 1) Mg, 2) PCl3 / 2) THF, hexane, -78 deg C 2: 1) AlCl3, 2) tributylphosphine / 1) CH2Cl2, -78 deg C, 15 min, 2) -78 deg C to r.t. View Scheme
参考文献
Nief, F.; Mathey, F.
Tetrahedron, 1991 , vol. 47, # 33 p. 6673 - 6680
反应条件
1: With potassium carbonate T=20°C; 0.25 h; 2: With dicobalt octacarbonyl; methyloxirane T=63°C;
参考文献
Khaibulova, T. Sh.; Boyarskaya; Boyarskii
Russian Journal of Organic Chemistry, 2013 , vol. 49, # 3 p. 360 - 365
Zh. Org. Khim., 2013 , vol. 49, # 3 p. 373 - 378
反应条件
1.1: Mg / tetrahydrofuran 1.2: 83 percent / tetrahydrofuran; CH2Cl2 / 2 h / 20 °C 2.1: 83 percent / MeLi / 12 h / 0 - 20 °C View Scheme
参考文献
Garratt, Dennis G.; Beaulieu, Pierre L.
Canadian Journal of Chemistry, 1980 , vol. 58, # 24 p. 2738 - 2744
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With n-butyllithium in tetrahydrofuran; hexane T=-70 - 0°C; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=0°C; 1 h; 3: With ammonia; iodine in tetrahydrofuran; hexane; water T=0 - 20°C;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 5 p. 958 - 964
反应条件
1: With magnesium in tetrahydrofuran T=20°C; 2 h; 2: With N,N-dimethyl-formamide in tetrahydrofuran T=0°C; 2 h; 3: With ammonia; iodine in tetrahydrofuran; water T=20°C; 2 h;
参考文献
Ishii, Genki; Harigae, Ryo; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2013 , vol. 69, # 5 p. 1462 - 1469
反应条件
tert.-butyl lithium in tetrahydrofuran; hexane T=-94°C;
参考文献
Rutan, Kimberly J.; Heldrich, Frederick J.; Borges, Lawrence F.
Journal of Organic Chemistry, 1995 , vol. 60, # 9 p. 2948 - 2950
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,2-Ph2-3,4-bis(2,4,6-(t-Bu)3-phenylphophinidene)cyclobutene; zinc in various solvent(s) T=100°C; 16 h;
参考文献
Jensen, Rader S.; Gajare, Anil S.; Toyota, Kozo; Yoshifuji, Masaaki; Ozawa, Fumiyuki
Tetrahedron Letters, 2005 , vol. 46, # 50 p. 8645 - 8647
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With magnesium; lithium chloride in tetrahydrofuran T=20°C; Inert atmosphere; 2: N-cyano-N-phenyl-p-methylbenzenesulfonamide in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Anbarasan, Pazhamalai; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2011 , vol. 17, # 15 p. 4217 - 4222
反应条件
tert.-butyl lithium in tetrahydrofuran; hexane T=-78°C; different reagents and reaction temperature; Product distribution;
参考文献
Rutan, Kimberly J.; Heldrich, Frederick J.; Borges, Lawrence F.
Journal of Organic Chemistry, 1995 , vol. 60, # 9 p. 2948 - 2950
