2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
hydrogenchloride; zinc(II) chloride
T=65 - 70°C; Einleiten von HCl;
参考文献
Fuson; Lindsey; Welldon
Journal of the American Chemical Society, 1942 , vol. 64, p. 2888,2890
反应条件
T=65 - 70°C; Einleiten von HCl;
参考文献
Fuson; Lindsey; Welldon
Journal of the American Chemical Society, 1942 , vol. 64, p. 2888,2890
反应条件
sodium; 1,3,5-trimethyl-benzene
T=150°C;
参考文献
Drozd,V.N.; Sheichenko,V.I.
Journal of Organic Chemistry USSR (English Translation), 1967 , vol. 3, p. 531 - 536
Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 3 p. 554 - 561
参考文献
Weiler
Chemische Berichte, 1900 , vol. 33, p. 344
反应条件
trichlorosilane; magnesium
1.) THF, 1 h 2.) reflux; Yield given. Multistep reaction;
参考文献
Baxter, S. G.; Mislow, Kurt; Blount, John F.
Tetrahedron, 1980 , vol. 36, # 2 p. 605 - 616
反应条件
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); C31H25F4O5P in 1,4-dioxane
T=110°C; Suzuki-Miyaura cross-coupling reaction; 24 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Potukuchi, Harish K.
Synlett, 2009 , # 17 p. 2852 - 2856
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With magnesium in tetrahydrofuran
RefluxInert atmosphere;
2: copper(l) chloride in tetrahydrofuran
T=-78 - 20°C; 25 h; Inert atmosphere;
参考文献
Pan, Xiaobo; Chen, Xiaoyu; Li, Tao; Li, Yizhi; Wang, Xinping
Journal of the American Chemical Society, 2013 , vol. 135, # 9 p. 3414 - 3417
反应条件
potassium phosphate; Pd(II) catalyst in tetrahydrofuran; toluene
T=110°C; Suzuki-Miyaura cross-coupling; 16 h;
参考文献
Chartoire, Anthony; Lesieur, Mathieu; Falivene, Laura; Slawin, Alexandra M. Z.; Cavallo, Luigi; Cazin, Catherine S. J.; Nolan, Steven P.
Chemistry - A European Journal, 2012 , vol. 18, # 15 p. 4517 - 4521
反应条件
magnesium
1.) THF, -78 deg C, 30 min, 2.) reflux, 50 h; Yield given. Multistep reaction;
参考文献
Eisch, John J.; Shafii, Babak; Odom, Jerome D.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1990 , vol. 112, # 5 p. 1847 - 1853
反应条件
1: 98 percent / RiekeTM-Mg
2: 82 percent / pyridine; DMAP
3: 54 percent / I2; PhI(OOCCF3)2
4: 47 percent / Et3N / Pd(PPh3)2Cl2
5: 96 percent / KF; 18-crown-6
6: 72 percent / TfOH / Au(PPh3)CH3 / methanol; H2O
7: 17 percent / N-methylimidazole / 2-methyl-propan-2-ol / Irradiation
View Scheme
参考文献
Wessig, Pablo; Teubner, Janek
Synlett, 2006 , # 10 p. 1543 - 1546
