2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
C30H21F6N2NiO2P in tetrahydrofuran
T=70°C; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Someya, Chika I.; Irran, Elisabeth; Enthaler, Stephan
Inorganica Chimica Acta, 2014 , vol. 421, p. 136 - 144
反应条件
1: With magnesium in diethyl ether
T=20°C; 0.5 h;
2: With zinc dibromide in diethyl ether
T=20°C; 6 h;
参考文献
Kanth, S. Ravi; Reddy, G. Venkat; Yakaiah; Narsaiah; Rao, P. Shanthan
Synthetic Communications, 2006 , vol. 36, # 20 p. 3079 - 3084
反应条件
[Pd(1,3-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene)(cinnamyl)Cl]; potassium 2-methyl-2-butoxide in 1,4-dioxane
T=110°C; Buchwald-Hartwig Coupling; 12 h; Inert atmosphereSealed tube;
参考文献
Bastug, Gulluzar; Nolan, Steven P.
Organometallics, 2014 , vol. 33, # 5 p. 1253 - 1258
反应条件
palladium diacetate; BIPHEP; copper(l) chloride in N,N-dimethyl-formamide
T=80°C; 14 h; Inert atmosphere;
参考文献
Li, Gao-Qiang; Yamamoto, Yasunori; Miyaura, Norio
Synlett, 2011 , # 12 p. 1769 - 1773
反应条件
[Pd(Cl){2-[OC(Ph)2CH2]-6-(3,5-Me2C3HN2)C5H3N}] in tetrahydrofuran; toluene
Kumada reaction; 24 h; Heating;
参考文献
Wang, Zhong-Xia; Chai, Zuo-Yun
European Journal of Inorganic Chemistry, 2007 , # 28 p. 4492 - 4499
反应条件
ammonia; KNH2
T=-33°C; Further byproducts given;
参考文献
Tremelling, Michael J.; Bunnett, J. F.
Journal of the American Chemical Society, 1980 , vol. 102, # 24 p. 7375 - 7377
反应条件
ammonia; KNH2
T=-33°C; Product distributionRate constant;
参考文献
Tremelling, Michael J.; Bunnett, J. F.
Journal of the American Chemical Society, 1980 , vol. 102, # 24 p. 7375 - 7377
反应条件
tert.-butyl lithium in tetrahydrofuran; hexane
T=-78°C; different reagents and reaction temperature; Product distribution;
参考文献
Rutan, Kimberly J.; Heldrich, Frederick J.; Borges, Lawrence F.
Journal of Organic Chemistry, 1995 , vol. 60, # 9 p. 2948 - 2950
反应条件
bis(η3-allyl-μ-chloropalladium(II)); triphenyl-phosphine oxide in 1,4-dioxane
T=100°C; 7 h; Inert atmosphere;
参考文献
Denmark, Scott E.; Werner, Nathan S.
Journal of the American Chemical Society, 2008 , vol. 130, # 48 p. 16382 - 16393
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene; (nBu)3MgLi in tetrahydrofuran; hexane
T=0°C; 0.5 h;
2: allyl bromide With CuCN*2LiCl in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Further stages.;
参考文献
Inoue; Kitagawa; Shinokubo; Oshima
Journal of Organic Chemistry, 2001 , vol. 66, # 12 p. 4333 - 4339
