2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With iodine; magnesium in tetrahydrofuran
2 h; RefluxInert atmosphere;
2: allyl bromide in tetrahydrofuran
T=20°C; Cooling with iceInert atmosphere;
参考文献
Lin, Song; Song, Chun-Xiao; Cai, Gui-Xin; Wang, Wen-Hua; Shi, Zhang-Jie
Journal of the American Chemical Society, 2008 , vol. 130, p. 12901 - 12903
反应条件
(i) Mg, (ii) /BRN= 2043396/; Multistep reaction;
参考文献
Wehrli; Heimgartner; Schmid; Hansen
Helvetica Chimica Acta, 1977 , vol. 60, # 6 p. 2034 - 2061
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With magnesium in tetrahydrofuran
T=20°C;
2: methylphosphonous dichloride in tetrahydrofuran; diethyl ether
Heating;
3: With lithium aluminium tetrahydride
T=20°C; 2.5 h; Further stages.;
参考文献
Blank, Natalia F.; Moncarz, Jillian R.; Brunker, Tim J.; Scriban, Corina; Anderson, Brian J.; Amir, Omar; Glueck, David S.; Zakharov, Lev N.; Golen, James A.; Incarvito, Christopher D.; Rheingold, Arnold L.
Journal of the American Chemical Society, 2007 , vol. 129, # 21 p. 6847 - 6858
反应条件
trichlorosilane; lithium in tetrahydrofuran
12 h; Heating;
参考文献
Gynane, Michael J. S.; Lappert, Michael F.; Riley, Paul I.; Riviere, Pierre; Riviere-Baudet, Monique
Journal of Organometallic Chemistry, 1980 , vol. 202, # 1 p. 5 - 12
反应条件
trichlorosilane; magnesium
1.) THF, 2.) ether, THF, 0 deg C; reflux, 1 h 30 min; Multistep reaction;
参考文献
Grajewska, Agnieszka; Oestreich, Martin
Synlett, 2010 , # 16 p. 2482 - 2484
反应条件
trichlorosilane; magnesium
1.) Et2O, reflux, 3 h, 2.) Et2O, RT, overnight; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Stueger, Harald
Journal of Organometallic Chemistry, 1993 , vol. 458, # 1-2 p. 1 - 8
反应条件
Yield given. Multistep reaction;
参考文献
Ayer; McCaskill
Canadian Journal of Chemistry, 1981 , vol. 59, # 14 p. 2159 - 2169
反应条件
palladium diacetate; 1,3-bis(alkyl)imidazolium chloride (LHX5); caesium carbonate in 1,4-dioxane
T=80°C; 24 h;
参考文献
Oezdemir, Ismail; Yigit, Murat; Cetinkaya, Engin; Cetinkaya, Bekir
Tetrahedron Letters, 2004 , vol. 45, # 30 p. 5823 - 5825
反应条件
1: AlCl3; carbon disulfide
2: POCl3; PCl3; PCl5 / 65 - 90 °C
3: sodium ethylate
View Scheme
参考文献
Adams; Theobald
Journal of the American Chemical Society, 1943 , vol. 65, p. 2383,2385
反应条件
tripotassium phosphate monohydrate in water; toluene
T=100°C; Suzuki-Miyaura cross-coupling; 1.5 h;
参考文献
Diebold, Carine; Becht, Jean-Michel; Lu, Jinni; Toy, Patrick H.; Le Drian, Claude
European Journal of Organic Chemistry, 2012 , # 5 p. 893 - 896
