2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
1: Mg / toluene; tetrahydrofuran
2: NaOH / diethyl ether
View Scheme
参考文献
Reuter, Hans; Puff, Heinrich
Journal of Organometallic Chemistry, 1989 , vol. 379, p. 223 - 234
反应条件
bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide
T=80°C; 3 h;
参考文献
Park, Kyungho; Bae, Goun; Moon, Jeongju; Choe, Jaehoon; Song, Kwang Ho; Lee, Sunwoo
Journal of Organic Chemistry, 2010 , vol. 75, # 18 p. 6244 - 6251
反应条件
potassium carbonate; i-Pr2NPPh2; palladium diacetate in tetrahydrofuran
T=65°C; 12 h;
参考文献
Zhang, Weiwei; Wu, Huayue; Liu, Zhiqing; Zhong, Ping; Zhang, Lin; Huang, Xiaobo; Cheng, Jiang
Chemical Communications, 2006 , # 46 p. 4826 - 4828
反应条件
bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide
T=110°C; 3 h;
参考文献
Park, Kyungho; Bae, Goun; Moon, Jeongju; Choe, Jaehoon; Song, Kwang Ho; Lee, Sunwoo
Journal of Organic Chemistry, 2010 , vol. 75, # 18 p. 6244 - 6251
反应条件
sodium tetrachloropalladium (II); copper(l) iodide; Cy2P(t-Bu); diisopropylamine
T=80°C; Sonogashira coupling; Inert atmosphere;
参考文献
Schilz, Marc; Plenio, Herbert
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2798 - 2807
反应条件
tert.-butyl lithium in diethyl ether; pentane
T=-78 - 20°C; 0.666667 h;
参考文献
Vedejs, Edwin; Lee, Namkyu
Journal of the American Chemical Society, 1995 , vol. 117, # 3 p. 891 - 899
反应条件
triethylamine; palladium diacetate
T=140°C; Heck coupling; 20 h;
参考文献
Handy, Scott T.
Synlett, 2006 , # 18 p. 3176 - 3178
反应条件
Ti(N[t-Bu](3,5-Me2C6H3))3 in benzene
T=20°C; Inert atmosphere;
参考文献
Cossairt, Brandi M.; Cummins, Christopher C.
New Journal of Chemistry, 2010 , vol. 34, # 8 p. 1533 - 1536
反应条件
iodine; magnesium
1.) THF, initiation with sonification, reflux, 1 h, 2.) THF, 0 deg C up to r.t.; Multistep reaction;
参考文献
Blount, John F.; Camp, David; Hart, Robert D.; Healy, Peter C.; Skelton, Brian W.; White, Allan H.
Australian Journal of Chemistry, 1994 , vol. 47, # 8 p. 1631 - 1640
反应条件
in diethyl ether; ammonia
Irradiation;
参考文献
Alonso, Ruben A.; Bardon, Alicia; Rossi, Roberto A.
Journal of Organic Chemistry, 1984 , vol. 49, # 19 p. 3584 - 3587
