2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
(i) Mg, MeI, Et2O, (ii) /BRN= 635680/; Multistep reaction;
参考文献
Adams,R.; Ferretti,A.
Journal of the American Chemical Society, 1961 , vol. 83, p. 2559 - 2563
反应条件
1: (i) Mg, MeI, Et2O, (ii) /BRN= 635680/
2: Na2CO3 / formic acid
3: H2 / PtO2 / acetic acid
View Scheme
参考文献
Adams,R.; Ferretti,A.
Journal of the American Chemical Society, 1961 , vol. 83, p. 2559 - 2563
反应条件
tris-(dibenzylideneacetone)dipalladium(0); (1,2,3,4,5-pentaphenylferrocen-1'-yl)-di-tert-butylphosphine in toluene
T=20°C; 1 h;
参考文献
Vila, Carlos; Giannerini, Massimo; Hornillos, Valentin; Fananas-Mastral, Martin; Feringa, Ben L.
Chemical Science, 2014 , vol. 5, # 4 p. 1361 - 1367
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With [Pd(1,3-bis(2,6-bis(diphenylmethyl)-4-methylphenyl)imidazol-2-ylidene)(cinnamyl)Cl]; potassium 2-methyl-2-butoxide in neat (no solvent)
T=25°C; Buchwald-Hartwig Coupling; 0.0833333 h;
2: 2,4,6-trimethylbenzenamine in neat (no solvent)
T=25°C; Buchwald-Hartwig Coupling; 0.05 h;
参考文献
Chartoire, Anthony; Boreux, Arnaud; Martin, Anthony R.; Nolan, Steven P.
RSC Advances, 2013 , vol. 3, # 12 p. 3840 - 3843
反应条件
sodium t-butanolate; palladium diacetate in toluene
18 h; Heating;
参考文献
Bedford, Robin B.; Betham, Michael
Tetrahedron Letters, 2007 , vol. 48, # 51 p. 8947 - 8950
反应条件
in diethyl ether
inert atmosphere; addn. of MesMgBr (prepared from Mg and MesBr) to GaCl3 soln., refluxing (16 h); solvent removal (vac.), repeated extn. (pentane), recrystn. (pentane), sublimation (160-170°C, vac.); elem. anal.;
参考文献
Beachley, O. T. Jr.; Churchill, Melvyn Rowen; Pazik, John C.; Ziller, Joseph W.
Organometallics, 1986 , vol. 5, p. 1814 - 1817
反应条件
1: 98 percent / RiekeTM-Mg
2: 82 percent / pyridine; DMAP
3: 54 percent / I2; PhI(OOCCF3)2
4: 47 percent / Et3N / Pd(PPh3)2Cl2
5: 96 percent / KF; 18-crown-6
6: 72 percent / TfOH / Au(PPh3)CH3 / methanol; H2O
7: 17 percent / N-methylimidazole / 2-methyl-propan-2-ol / Irradiation
8: 91 percent / K2CO3 / methanol
9: 43 percent / LDA
View Scheme
参考文献
Wessig, Pablo; Teubner, Janek
Synlett, 2006 , # 10 p. 1543 - 1546
参考文献
Smith; Moyle
Journal of the American Chemical Society, 1936 , vol. 58, p. 1,9
参考文献
Smith; Moyle
Journal of the American Chemical Society, 1936 , vol. 58, p. 1,9
参考文献
Fuson; Lindsey; Welldon
Journal of the American Chemical Society, 1942 , vol. 64, p. 2888,2890
