2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
caesium carbonate; 1,4-di(diphenylphosphino)-butane; palladium diacetate in ethylene glycol dimethyl ether; water
T=50°C; 24 h;
参考文献
Batey, Robert A; Quach, Tan D
Tetrahedron Letters, 2001 , vol. 42, # 52 p. 9099 - 9103
反应条件
palladium diacetate; Ipr.HCl; tetrabutyl ammonium fluoride in tetrahydrofuran; 1,4-dioxane
T=80°C; 48 h;
参考文献
Grasa, Gabriela A.; Nolan, Steven P.
Organic Letters, 2001 , vol. 3, # 1 p. 119 - 120
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tetrabutyl ammonium fluoride; 3-tert-butyl-5-methyl-1-(2-(diphenylphosphino)phenyl)-1H-pyrazole in 1,4-dioxane
T=55°C; Hiyama coupling; 10 h; Inert atmosphere;
参考文献
Pal, Anwesha; Ghosh, Raju; Adarsh; Sarkar, Amitabha
Tetrahedron, 2010 , vol. 66, # 29 p. 5451 - 5458
反应条件
[(P{(NC5H10)(C6H11)2})2Pd(Cl)2] in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; 0.166667 h; In air;
参考文献
Bolliger, Jeanne L.; Frech, Christian M.
Chemistry - A European Journal, 2010 , vol. 16, # 36 p. 11072 - 11081
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; cesium fluoride; 3-tert-butyl-5-methyl-1-(2-(diphenylphosphino)phenyl)-1H-pyrazole in toluene
T=60°C; Stille coupling; 10 h; Inert atmosphere;
参考文献
Pal, Anwesha; Ghosh, Raju; Adarsh; Sarkar, Amitabha
Tetrahedron, 2010 , vol. 66, # 29 p. 5451 - 5458
反应条件
cis-P,P'-(η5-cyclopentadienyl)-{5,17-bis(diphenylphosphino)-25,26,27,28-tetrabenzyloxycalix[4]arene}nickel(II) tetrafluoroborate in tetrahydrofuran; 1,4-dioxane
T=100°C; Kumada-Tamao-Corriu cross-coupling; 1 h; Inert atmosphere;
参考文献
Monnereau, Laure; Semeril, David; Matt, Dominique; Toupet, Loic; Mota, Antonio J.
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 9 p. 1383 - 1389
反应条件
1: PhMgX, X = halide With zinc(II) chloride in tetrahydrofuran
T=25°C; 0.25 h; Inert atmosphere;
2: 2-Bromo-1,3,5-trimethyl-benzene With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
1: methyl-phenyl-thioether With C30H21F6N2NiO2P in tetrahydrofuran
Schlenk techniqueInert atmosphere;
2: 2-Bromo-1,3,5-trimethyl-benzene With magnesium; lithium chloride in tetrahydrofuran
T=70°C; 24 h;
参考文献
Someya, Chika I.; Weidauer, Maik; Enthaler, Stephan
Catalysis Letters, 2013 , vol. 143, # 5 p. 424 - 431
反应条件
diethyl ether; magnesium
参考文献
Smith; Kiess
Journal of the American Chemical Society, 1939 , vol. 61, p. 284,287
反应条件
sodium; xylene
T=180°C;
参考文献
Toehl; Tripke
Chemische Berichte, 1895 , vol. 28, p. 2462
Full Text Show Details
Jannasch; Wigner
Chemische Berichte, 1895 , vol. 28, p. 2028
