2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
cesium hydroxide monohydrate; Pd(CH2SiMe3)2(cod); 2-(di-1-adamantylphosphanyl)-1-(2,6-diisopropylphenyl)-1H-imidazole in tetrahydrofuran T=24°C; 20 h; Inert atmosphere;
参考文献
Sergeev, Alexey G.; Schulz, Thomas; Torborg, Christian; Spannenberg, Anke; Neumann, Helfried; Beller, Matthias
Angewandte Chemie, International Edition, 2009 , vol. 48, # 41 p. 7595 - 7599
反应条件
potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); 2-(di-1-adamantylphosphanyl)-1-(2,6-diisopropylphenyl)-1H-imidazole in 1,4-dioxane; water T=100°C; 20 h;
参考文献
Schulz, Thomas; Torborg, Christian; Schaeffner, Benjamin; Huang, Jun; Zapf, Alexander; Kadyrov, Renat; Boerner, Armin; Beller, Matthias
Angewandte Chemie - International Edition, 2009 , vol. 48, # 5 p. 918 - 921
反应条件
1: With boric acid trimethyl ester T=20°C; Electrochemical reactionMg consumable anode, supporting electrolyte; 2: T=0°C; Acid hydrolysis; Further stages.;
参考文献
Laza, Carine; Dunach, Elisabet; Serein-Spirau, Francoise; Moreau, Joel J. E.; Vellutini, Luc
New Journal of Chemistry, 2002 , vol. 26, # 4 p. 373 - 375
反应条件
2-t-butylperoxy-1,3,2-dioxaborolane; magnesium 1.) THF, 2.) THF, overnight; reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hoffmann, Reinhard W.; Ditrich, K.
Synthesis, 1983 , # 2 p. 107 - 109
反应条件
1: 1.) BuLi / 1.) ether, hexane, reflux, 1 h, 2.) 1 h, reflux 2: 1.) air, CH3COOH, 2.) DDQ / 1.) ethylbenzene, reflux, 4 h, 2.) CH2Cl2, reflux, 3 h View Scheme
参考文献
Volz, Heinrich; Hassler, Michael; Schaeffer, Hermann
Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1986 , vol. 41, # 10 p. 1265 - 1272
反应条件
sodium t-butanolate; (SIPr)Pd(allyl)Cl in tetrahydrofuran T=60°C; 6 h;
参考文献
Organic Letters, , vol. 4, # 23 p. 4053 - 4055
反应条件
1: With Co(2,2'-bipyridine)Br2; silver nitrate in N,N-dimethyl-formamide T=25°C; Electrochemical reaction; 2: Acid hydrolysis;
参考文献
Budnikova; Kafiyatullina; Kargin; Sinyashin
Russian Chemical Bulletin, 2002 , vol. 51, # 9 p. 1702 - 1708
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=0°C; Flow reactor; 2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran; hexane T=0°C; Flow reactor; Reagent/catalyst;
参考文献
Chemistry - An Asian Journal, , vol. 8, # 4 p. 705 - 708
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With magnesium in tetrahydrofuran 6 h; Heating; 2: 2,4,6-tribromo-1-iodobenzene With magnesium in tetrahydrofuran Heating; 3: With hydrogenchloride cooling;
参考文献
Ritleng, Vincent; Yandulov, Dmitry V.; Weare, Walter W.; Schrock, Richard R.; Hock, Adam S.; Davis, William M.
Journal of the American Chemical Society, 2004 , vol. 126, # 19 p. 6150 - 6163
反应条件
1,1-di(phenyl)ethylene in various solvent(s) 2 h; Heating;
参考文献
Journal of the American Chemical Society, , vol. 107, # 18 p. 5271 - 5272
