2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
sodium methylate in N,N,N',N',N'',N''-hexamethylphosphoric triamide
参考文献
Organic letters, , vol. 3, # 8 p. 1197 - 1200
反应条件
ammonia; KNH2 T=-33°C; Further byproducts given;
参考文献
Journal of the American Chemical Society, , vol. 102, # 24 p. 7375 - 7377
反应条件
n-butyllithium in hexane 2-bromomesitylene (1 equiv.) and TMTH (1 equiv.) in hexane cooled to 0°C under Ar, n-BuLi (1 equiv., 2.40 M in hexane) added, stirred for 5 h at reflux temp., quenched with water; analyzed by GC;
参考文献
Organometallics, , vol. 6, p. 557 - 565
反应条件
tert-butyl N,N,N',N'-tetraisopropylphosphorodiamidite; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate in toluene T=105°C; Buchwald-Hartwig Coupling; 5 h; Inert atmosphereSchlenk technique;
参考文献
Roiban, Gheorghe-Doru; Mehler, Gerlinde; Reetz, Manfred T.
European Journal of Organic Chemistry, 2014 , vol. 2014, # 10 p. 2070 - 2076
反应条件
magnesium in N,N-dimethyl-formamide byproducts: Mg(2+); Electrolysis; electrolysis carried out in a single-compartment cell at room temp., starting materials dissolved in DMF containing KBr or n-Bu4NBr, solvent andexcess B(OCH3)3 evaporated under vacuum, medium hydrolysed at 0° C with an HCl or H2SO4 soln.; extraction with Et2O (3 x 20 ml if the solvent evaporated or 3 x 60 ml otherwise), organic phase dried over sodium or magnesium sulfate and concentrated under vacuum, side product phenol formation avoided by work-up under inert atmosphere;
参考文献
Laza, Carine; Dunach, Elisabet; Serein-Spirau, Francoise; Moreau, Joel J. E.; Vellutini, Luc
New Journal of Chemistry, 2002 , vol. 26, # 4 p. 373 - 375
反应条件
sodium amide in diethyl ether; ammonia 2 h; Irradiation;
参考文献
Journal of Organic Chemistry, , vol. 49, # 19 p. 3584 - 3587
反应条件
ammonia; KNH2 T=-33°C; Product distributionRate constant;
参考文献
Journal of the American Chemical Society, , vol. 102, # 24 p. 7375 - 7377
反应条件
1: With boric acid trimethyl ester T=20°C; Electrochemical reactionMg consumable anode, supporting electrolyte; 2: T=0°C; Acid hydrolysis; Further stages.;
参考文献
Laza, Carine; Dunach, Elisabet; Serein-Spirau, Francoise; Moreau, Joel J. E.; Vellutini, Luc
New Journal of Chemistry, 2002 , vol. 26, # 4 p. 373 - 375
反应条件
2-t-butylperoxy-1,3,2-dioxaborolane; magnesium 1.) THF, 2.) THF, overnight; reflux, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hoffmann, Reinhard W.; Ditrich, K.
Synthesis, 1983 , # 2 p. 107 - 109
反应条件
tert.-butyl lithium in tetrahydrofuran; hexane T=-78°C; different reagents and reaction temperature; Product distribution;
参考文献
Rutan, Kimberly J.; Heldrich, Frederick J.; Borges, Lawrence F.
Journal of Organic Chemistry, 1995 , vol. 60, # 9 p. 2948 - 2950
