2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
dioxathion; caesium carbonate; palladium dichloride in tetrahydrofuran; water T=85°C; Suzuki-Miyaura reaction; 22 h;
参考文献
Molander, Gary A.; Brown, Adam R.
Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9681 - 9686
反应条件
cis,cis,cis-tetrakis[(diphenylphosphanyl)methyl]cyclopentane; potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)) in xylene T=130°C; Suzuki reaction; 20 h;
参考文献
Peyroux, Eugenie; Berthiol, Florian; Doucet, Henri; Santelli, Maurice
European Journal of Organic Chemistry, 2004 , # 5 p. 1075 - 1082
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate in tetrahydrofuran; water T=150°C; Suzuki-Miyaura coupling; P=7757.43 - 9050.33 Torr; 1 h; Inert atmosphereMicrowave irradiation;
参考文献
Brooker, Matthew D.; Cooper Jr., Stefan M.; Hodges, Dena R.; Carter, Rhiannon R.; Wyatt, Justin K.
Tetrahedron Letters, 2010 , vol. 51, # 51 p. 6748 - 6752
反应条件
palladium diacetate; Ipr.HCl; tetrabutyl ammonium fluoride in tetrahydrofuran; 1,4-dioxane T=80°C; 48 h;
参考文献
Grasa, Gabriela A.; Nolan, Steven P.
Organic Letters, 2001 , vol. 3, # 1 p. 119 - 120
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; caesium carbonate in tetrahydrofuran; water T=85 - 90°C; 168 h;
参考文献
Carter, Rhiannon R.; Wyatt, Justin K.
Tetrahedron Letters, 2006 , vol. 47, # 34 p. 6091 - 6094
反应条件
tetrabutyl ammonium fluoride; palladium (II) bromide; biphenyl-2-yl-di-tert-butyl-phosphane in tetrahydrofuran T=50°C; 48 h;
参考文献
Denmark, Scott E.; Butler, Christopher R.
Organic Letters, 2006 , vol. 8, # 1 p. 63 - 66
反应条件
1: With magnesium in tetrahydrofuran Metallation; 2: With phosphorus trichoride in tetrahydrofuran T=-78 - 20°C; Substitution;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 72, # 3 p. 563 - 572
反应条件
1: magnesium / tetrahydrofuran / 4 h / 20 °C / |Inert atmosphere; |Schlenk technique 2: phosphorus trichoride / tetrahydrofuran / 12 h / -78 - 20 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Inorganic Chemistry, , vol. 52, # 11 p. 6694 - 6704
反应条件
1: With diisobutylaluminium hydride; magnesium; lithium chloride in tetrahydrofuran; toluene T=20°C; 15 h; Inert atmosphere; 2: With boric acid trimethyl ester in tetrahydrofuran; toluene T=0°C; Inert atmosphere; 3: With hydrogenchloride; water in tetrahydrofuran; toluene T=0°C; Inert atmosphere;
参考文献
Leermann, Timo; Leroux, Frederic R.; Colobert, Francoise
Organic Letters, 2011 , vol. 13, # 17 p. 4479 - 4481
反应条件
magnesium in N,N-dimethyl-formamide byproducts: Mg(2+); Electrolysis; electrolysis carried out in a single-compartment cell at room temp., starting materials dissolved in DMF containing KBr or n-Bu4NBr, solvent andexcess B(OCH3)3 evaporated under vacuum, medium hydrolysed at 0° C with an HCl or H2SO4 soln.; extraction with Et2O (3 x 20 ml if the solvent evaporated or 3 x 60 ml otherwise), organic phase dried over sodium or magnesium sulfate and concentrated under vacuum, side product phenol formation avoided by work-up under inert atmosphere;
参考文献
Laza, Carine; Dunach, Elisabet; Serein-Spirau, Francoise; Moreau, Joel J. E.; Vellutini, Luc
New Journal of Chemistry, 2002 , vol. 26, # 4 p. 373 - 375
