2-溴-1,3,5-三甲基苯合成路线 （共 240 条）
反应条件
1: With boric acid trimethyl ester T=20°C; Electrochemical reactionMg consumable anode, supporting electrolyte; 2: T=0°C; Acid hydrolysis; Further stages.;
参考文献
Laza, Carine; Dunach, Elisabet; Serein-Spirau, Francoise; Moreau, Joel J. E.; Vellutini, Luc
New Journal of Chemistry, 2002 , vol. 26, # 4 p. 373 - 375
反应条件
1: 2-Bromo-1,3,5-trimethyl-benzene With n-butyllithium in tetrahydrofuran; hexane T=-20°C; 0.00130833 h; Flow reactor; 2: oxalic acid diethyl ester in tetrahydrofuran; hexane T=-20°C; 0.000466667 h; Flow reactor; 3: With water; acetic acid in tetrahydrofuran; hexane Temperature;
参考文献
Nagaki, Aiichiro; Ichinari, Daisuke; Yoshida, Jun-Ichi
Chemical Communications, 2013 , vol. 49, # 31 p. 3242 - 3244
反应条件
1.1: butyllithium / tetrahydrofuran 1.2: 90 percent / tetrahydrofuran / 0.5 h / -78 °C 2.1: 96 percent / pyridinium chlorochromate / CH2Cl2 / 20 °C View Scheme
参考文献
Grilli; Lunazzi; Mazzanti; Casarini; Femoni
Journal of Organic Chemistry, 2001 , vol. 66, # 2 p. 488 - 495
反应条件
sulfuric acid T=25 - 30°C;
参考文献
Smith; Moyle
Journal of the American Chemical Society, 1936 , vol. 58, p. 1,9
参考文献
Smith; Moyle
Journal of the American Chemical Society, 1936 , vol. 58, p. 1,9
参考文献
Lutz; Kibler
Journal of the American Chemical Society, 1940 , vol. 62, p. 1520,1522
Full Text Show Details
Lutz; Wood
Journal of the American Chemical Society, 1938 , vol. 60, p. 713,715
反应条件
Product distribution;
参考文献
Yannai, Michal Beit; Rappoport, Zvi
Journal of Organic Chemistry, 1996 , vol. 61, # 10 p. 3553 - 3556
反应条件
(i) Mg, (ii) formic acid alkyl ester; Multistep reaction;
参考文献
Lapkin,L.I. et al.
Journal of Organic Chemistry USSR (English Translation), 1971 , vol. 7, p. 2366 - 2368
Zhurnal Organicheskoi Khimii, 1971 , vol. 7, # 11 p. 2276 - 2278
反应条件
1: With potassium carbonate; Pd-Tedicyp catalyst in N,N-dimethyl-formamide T=110°C; Heck reaction; 20 h; 2: With hydrogenchloride in N,N-dimethyl-formamide
参考文献
Lemhadri, Mhamed; Doucet, Henri; Santelli, Maurice
Tetrahedron, 2004 , vol. 60, # 50 p. 11533 - 11540
反应条件
1: Mg / toluene; tetrahydrofuran 2: KF / water; acetone View Scheme
参考文献
Reuter, Hans; Puff, Heinrich
Journal of Organometallic Chemistry, 1989 , vol. 379, p. 223 - 234
