4-(3-氯丙基)吗啉盐酸盐合成路线 （共 7 条）
反应条件
1: in toluene T=84°C; 3 h; 2: With hydrogenchloride in 1,4-dioxane; toluene
参考文献
Bayer Pharma Aktiengesellschaft; SCOTT, William Johnston; PETROV, Orlin
Patent: WO2012/62743 A1, 2012 ;
Location in patent: Page/Page column 58 ;
WO 2012/062743 A1
反应条件
1: With potassium carbonate in N,N-dimethyl-formamide 16 h; 2: With hydrogenchloride in 1,4-dioxane; diethyl ether
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/20415 A1, 2006 ;
Location in patent: Page/Page column 137 ;
WO 2006/020415 A1
反应条件
potassium carbonate in acetonitrile 2.5 h; Reflux;
参考文献
IND-SWIFT LABORATORIES LIMITED; AGGARWAL, Ashvin, Kumar; JAIN, Anshul, Kumar; CHIDAMBARAM, Venkateswaran, Srinivasan; WADHWA, Lalit
Patent: WO2010/76810 A2, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=90°C; 5 h;
参考文献
WO2005/30140 A2, ;
Page/Page column 209 ;
WO 2005/030140 A2
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C / |Inert atmosphere
2: hydrogen; 5 palladium on charcoal / methanol / 4 h / 20 °C
View Scheme
参考文献
Pan, Xiaoyan; Dong, Jinyun; Gao, Hongping; Wang, Fang; Zhang, Yanmin; Wang, Sicen; Zhang, Jie
Chemical Biology and Drug Design, 2014 , vol. 83, # 5 p. 592 - 599
参考文献
Doherty et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 5667,5670
Full Text Show Details
Clinton et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 3366,3368
反应条件
trichloroethane, 1,1,1-; potassium carbonate
参考文献
Di Paco; Tauro
Farmaco, Edizione Scientifica, 1958 , vol. 13, p. 64,72, 73
