2,2-二甲基苯乙酸甲酯合成路线 （共 49 条）
反应条件
1: With sodium hydride in tetrahydrofuran T=0 - 25°C; 18 h; 2: With acetic acid in tetrahydrofuran T=0°C;
参考文献
ABBOTT LABORATORIES
Patent: WO2005/19191 A2, 2005 ;
Location in patent: Page/Page column 141 ;
WO 2005/019191 A2
反应条件
tri-tert-butyl phosphine; LiN(Cy)2; bis(dibenzylideneacetone)-palladium(0) in toluene T=20°C; 18 h;
参考文献
Jorgensen, Morten; Lee, Sunwoo; Liu, Xiaoxiang; Wolkowski, Joanna P.; Hartwig, John F.
Journal of the American Chemical Society, 2002 , vol. 124, # 42 p. 12557 - 12565
反应条件
sulfuric acid T=70°C; 12 h;
参考文献
Yu, Zhoujie; Wang, Wei; Chen, Liqin
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 7 p. 352 - 356
反应条件
1: 2-methylpropanoic acid methyl ester With sodium hexamethyldisilazane in toluene T=20°C; 0.166667 h; Inert atmosphere; 2: chlorobenzene With [P(t-Bu)3Pd(μ-Br)]2 in toluene T=100°C; 4 h; Inert atmosphere;
参考文献
Hama, Takuo; Hartwig, John F.
Organic Letters, 2008 , vol. 10, # 8 p. 1549 - 1552
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide T=20°C; 40 h;
参考文献
US2006/276508 A1, ;
Page/Page column 31 ;
US 20060276508 A1
反应条件
(i) NaNH2, liq. NH3, (ii) /BRN= 969135/; Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1347 - 1352
反应条件
ZnF2; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl-formamide T=80°C; 12 h;
参考文献
Hama, Takuo; Liu, Xiaoxiang; Culkin, Darcy A.; Hartwig, John F.
Journal of the American Chemical Society, 2003 , vol. 125, # 37 p. 11176 - 11177
反应条件
5-chloro-2-hydroxy-benzoic acid; boric acid; tris(4-methylphenyl)-phosphine; palladium diacetate P=31028.9 Torr; 48 h; Heating;
参考文献
Vieira, Tiago O.; Green, Mike J.; Alper, Howard
Organic Letters, 2006 , vol. 8, # 26 p. 6143 - 6145
反应条件
pyridine T=0 - 20°C; 2 h;
参考文献
WO2005/19175 A1, ;
Page/Page column 24 ;
反应条件
potassium tert-butylate in tetrahydrofuran
参考文献
DuPont Pharmaceuticals Company
Patent: US6060462 A1, 2000 ;
US 6060462 A
