1,1-二(羟甲基)环戊烷合成路线 （共 17 条）
反应条件
CuSO4‵5H2O in methanol T=100°C; 0.25 h; Microwave irradiation;
参考文献
Gonzalez-Calderon, Davir; Benitez-Puebla, Luis J.; Gonzalez-Gonzalez, Carlos A.; Assad-Hernandez, Salomon; Fuentes-Benitez, Aydee; Cuevas-Yanez, Erick; Corona-Becerril, David; Gonzalez-Romero, Carlos
Tetrahedron Letters, 2013 , vol. 54, # 37 p. 5130 - 5132
反应条件
lithium aluminium tetrahydride
参考文献
Houk,J.; Whitesides,G.M.
Journal of the American Chemical Society, 1987 , vol. 109, p. 6825
反应条件
CuSO4‵5H2O in methanol T=50°C; 12 h;
参考文献
Gonzalez-Calderon, Davir; Benitez-Puebla, Luis J.; Gonzalez-Gonzalez, Carlos A.; Assad-Hernandez, Salomon; Fuentes-Benitez, Aydee; Cuevas-Yanez, Erick; Corona-Becerril, David; Gonzalez-Romero, Carlos
Tetrahedron Letters, 2013 , vol. 54, # 37 p. 5130 - 5132
反应条件
1: 59 percent / pyridine 2: 83 percent / LiBr / 2-ethoxy-ethanol 3: 88 percent / Zn, ethylenediaminetetraacetic acid tetrasodium salt / ethanol View Scheme
参考文献
Slobodin; Blinowa
Zhurnal Obshchei Khimii, 1954 , vol. 24, p. 621,624; engl. Ausg. S. 633, 635
反应条件
sulfuric acid T=150 - 155°C; 48 h;
参考文献
Tetrahedron, , vol. 48, # 23 p. 4929 - 4936
反应条件
pyridine anschliessendes Behandeln mit fluessigem NH3;
参考文献
Bourdais,J.
Bulletin de la Societe Chimique de France, 1962 , p. 266 - 267
反应条件
1.1: triethylamine / dichloromethane / 0.5 h / |Inert atmosphere; |Cooling 1.2: -3 - 20 °C / |Inert atmosphere 2.1: N,N-dimethyl-formamide / 100 °C / |Inert atmosphere 3.1: water; sodium hydroxide / ethanol / |Inert atmosphere; |Reflux 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / |Inert atmosphere; |Reflux View Scheme
参考文献
BETA PHARMA CANADA INC; ASTAR BIOTECH LLC; WANG, Zhaoyin; LI, Lianhai
Patent: WO2013/185202 A1, 2013 ;
反应条件
1: phosphorus (III)-bromide / 150 °C 2: aqueous ethanol; zinc View Scheme
参考文献
Zhurnal Obshchei Khimii, , vol. 24, p. 621,624; engl. Ausg. S. 633, 635
反应条件
1.1: triethylamine / dichloromethane / 0.5 h / |Inert atmosphere; |Cooling 1.2: -3 - 20 °C / |Inert atmosphere 2.1: N,N-dimethyl-formamide / 100 °C / |Inert atmosphere 3.1: water; sodium hydroxide / ethanol / |Inert atmosphere; |Reflux View Scheme
参考文献
BETA PHARMA CANADA INC; ASTAR BIOTECH LLC; WANG, Zhaoyin; LI, Lianhai
Patent: WO2013/185202 A1, 2013 ;
