5-溴-3-(三氟甲基)-1H-吲唑合成路线 （共 5 条）
反应条件
hydrazine in butan-1-ol
6 h; Heating / reflux;
参考文献
AMR TECHNOLOGY, INC.
Patent: WO2008/86404 A1, 2008 ;
Location in patent: Page/Page column 126-127 ;
WO 2008/086404 A1
反应条件
sodium nitrite in water; acetic acid
参考文献
Produits Chimiques Ugine Kuhlmann
Patent: US4051145 A1, 1977 ;
反应条件
N-bromosuccinmide in acetonitrile
T=20°C; 48 h;
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
反应条件
1: acetic acid; sodium nitrite / H2O / 72 h / 20 °C
2: 35 percent / N-bromosuccinimide / acetonitrile / 48 h / 20 °C
View Scheme
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in acetonitrile
T=20°C; 5 h;
参考文献
Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Woods, Keith; Luo, Yan; Liu, Xuesong; Guan, Ran; Klinghofer, Vered; Johnson, Eric F.; Stoll, Vincent S.; Mamo, Mulugeta; Li, Qun; Rosenberg, Saul H.; Giranda, Vincent L.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 6 p. 2441 - 2452
