3-(4-嘧啶-2-哌嗪)-1-丙胺合成路线 （共 4 条）
反应条件
trifluoroacetic acid in dichloromethane
T=10 - 20°C;
参考文献
Gagliardi, Stefania; Nadler, Guy; Consolandi, Emanuela; Parini, Carlo; Morvan, Marcel; Legave, Marie-Noeelle; Belfiore, Pietro; Zocchetti, Andrea; Clarke, Geoffrey D.; James, Ian; Nambi, Ponnal; Gowen, Maxine; Farina, Carlo
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1568 - 1573
反应条件
lithium aluminium tetrahydride in diethyl ether
T=-10°C; 2 h;
参考文献
Ishizumi; Kojima; Antoku
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300
反应条件
1: 43 percent / K2CO3 / acetonitrile / 4 h / Heating
2: 83 percent / TFA / CH2Cl2 / 10 - 20 °C
View Scheme
参考文献
Gagliardi, Stefania; Nadler, Guy; Consolandi, Emanuela; Parini, Carlo; Morvan, Marcel; Legave, Marie-Noeelle; Belfiore, Pietro; Zocchetti, Andrea; Clarke, Geoffrey D.; James, Ian; Nambi, Ponnal; Gowen, Maxine; Farina, Carlo
Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1568 - 1573
反应条件
hydrazine hydrate
Multistep reaction;
参考文献
He, Xiao Shu; Woodruff, Kristine; Brodbeck, Robbin
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2399 - 2402
