5-(2-硝基苯基)-2-糠腈合成路线 （共 5 条）
反应条件
acetic anhydride
2.5 h; Heating;
参考文献
Pong; Pelosi Jr.; Wessels; Yu; Burns; White; Anthony Jr.; Ellis; Wright; White Jr.
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 10 p. 1411 - 1416
反应条件
1: 1.) NaNO2, conc. HCl; 2.) CuCl2*2H2O / 1.) water, 0.5 h, 0 to 5 deg C; 2.) acetone, 0 deg C
2: 93 percent / NH2OH*HCl, NaOAc / ethanol; H2O / 3.5 h / Heating
3: 75 percent / Ac2O / 2.5 h / Heating
View Scheme
参考文献
Pong; Pelosi Jr.; Wessels; Yu; Burns; White; Anthony Jr.; Ellis; Wright; White Jr.
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 10 p. 1411 - 1416
反应条件
1: 93 percent / NH2OH*HCl, NaOAc / ethanol; H2O / 3.5 h / Heating
2: 75 percent / Ac2O / 2.5 h / Heating
View Scheme
参考文献
Pong; Pelosi Jr.; Wessels; Yu; Burns; White; Anthony Jr.; Ellis; Wright; White Jr.
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 10 p. 1411 - 1416
反应条件
1: 1.) NaNO2, conc. HCl; 2.) CuCl2*2H2O / 1.) water, 0.5 h, 0 to 5 deg C; 2.) acetone, 0 deg C
2: 93 percent / NH2OH*HCl, NaOAc / ethanol; H2O / 3.5 h / Heating
3: 75 percent / Ac2O / 2.5 h / Heating
View Scheme
参考文献
Pong; Pelosi Jr.; Wessels; Yu; Burns; White; Anthony Jr.; Ellis; Wright; White Jr.
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 10 p. 1411 - 1416
反应条件
sodium azide; ammonium chloride in N,N-dimethyl-formamide
参考文献
Povazanec,F. et al.
Collection of Czechoslovak Chemical Communications, 1976 , vol. 41, p. 1692 - 1697
