1,1'-(4-溴丁亚基)二[4-氟苯]合成路线 （共 12 条）
反应条件
sodium carbonate; potassium iodide in toluene Heating;
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
sodium carbonate; potassium iodide in toluene 66 h; Heating;
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
palladium 10 on activated carbon; hydrogen in ethanol
T=20°C;
参考文献
Chen, Gang; Xia, Hongguang; Cai, Yu; Ma, Dawei; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 234 - 239
反应条件
bromine; triphenylphosphine in acetonitrile
T=20°C; 2 h;
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 85 percent / diethyl ether; tetrahydrofuran / 5 h / Heating
2: 93 percent / H2 / HRh(CO)(PPh3)3 / toluene / 5 h / 60 °C / 76000 Torr
3: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C
4: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating
5: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C
View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 61 percent / PPh3; H2 / HRh(CO)(PPh3)3 / toluene / 24 h / 100 °C / 76000 Torr
2: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C
3: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating
4: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C
View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 93 percent / H2 / HRh(CO)(PPh3)3 / toluene / 5 h / 60 °C / 76000 Torr
2: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C
3: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating
4: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C
View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C
2: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating
3: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C
View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating
2: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C
View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: AlCl3
2: Na<AlH2(OCH2CH2OMe)2>
3: aq. HBr, H2SO4
View Scheme
参考文献
Rajsner; Kopicova; Holubek; et al.
Collection of Czechoslovak Chemical Communications, 1978 , vol. 43, # 7 p. 1760 - 1777
